ID   C1H8M2_PARBA            Unreviewed;       734 AA.
AC   C1H8M2;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Spindle assembly checkpoint component MAD1 {ECO:0000256|ARBA:ARBA00022019};
GN   ORFNames=PAAG_07113 {ECO:0000313|EMBL:EEH36695.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH36695.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH36695.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the MAD1 family.
CC       {ECO:0000256|ARBA:ARBA00008029}.
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DR   EMBL; KN294013; EEH36695.2; -; Genomic_DNA.
DR   RefSeq; XP_015700568.1; XM_015846133.1.
DR   AlphaFoldDB; C1H8M2; -.
DR   STRING; 502779.C1H8M2; -.
DR   GeneID; 9094183; -.
DR   KEGG; pbl:PAAG_07113; -.
DR   VEuPathDB; FungiDB:PAAG_07113; -.
DR   eggNOG; KOG4593; Eukaryota.
DR   HOGENOM; CLU_010064_1_0_1; -.
DR   OMA; YKLDFMP; -.
DR   OrthoDB; 2787310at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 3.30.457.60; -; 1.
DR   Gene3D; 6.10.250.90; -; 1.
DR   InterPro; IPR008672; Mad1.
DR   PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR   PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR   Pfam; PF05557; MAD; 1.
DR   SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          344..378
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          490..531
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          555..611
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  82970 MW;  F4659994B6F7BD3C CRC64;
     MSSGRFATTQ PTYDFITGAS SPSTSSGGGP GAANASFRQS IRSGQPPTKP VTDAGNEELR
     VQLSTLRYEL DNLKQERDLT ALHHEKELRE LQIRADADFR KAQAAISSSN KAQHKIESIA
     AELKTTQESA INEKASFDKQ LRSLQDRNQS LQEEFDDAQS QLSDRERQYS HQIHELEAIR
     SSLQKTLDEV QTELHETKDS LRSAQDKLAQ READMGMLES ENIRLKSEGA NSETLSVLQR
     ELSEQVAQVK RLEAELRPLR KSQKNVEIVE EQKKALENQL QLMQGVEVEL RNVQIQKQIL
     EDERRSWTSL LQTDGQNTEF DSPEEVARAL VQARIENASL LDRIGTIQTE MAEKAEMVQN
     LETEKSKLQR EIEKLRANGS AGSGADARAK TRLERQRVLA IREVEYLRAQ LKTFDTEETT
     MNADDTTFDQ QKSDHIAHLE NLLSEHREEL HKLHEELSKL EKASGEDANA PRGVKRPLSP
     AESDADSERL AVLVRKNRTL QDKLSKVEQS TELLTRELEA TKSQLSALQA QSQTRILELR
     SNPTAEAENV KLSTLTALRA ENRDLLAQLR NKHSNLKVVP LSTLESKEME LREMEKTVAE
     KDKRMRRLKE IWTAKSSEFR EAVASVLGYK LDFLPNGRVR VTSMFHLSPA YRHGDRDASP
     DVRGPGSMGD GEENSIIFDG ENGTMKISGG PNSLFAMEIR SLIKFWVEER KDIPCFLAAM
     TLDFYDKTTR AARM
//