ID C1LIY4_SCHJA Unreviewed; 445 AA.
AC C1LIY4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 28-JUN-2023, entry version 27.
DE SubName: Full=26S proteasome non-ATPase regulatory subunit 12 isoform 2 {ECO:0000313|EMBL:TNN20340.1};
DE SubName: Full=Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 {ECO:0000313|EMBL:CAX74662.1};
GN Name=Psmd12 {ECO:0000313|EMBL:CAX74662.1};
GN ORFNames=EWB00_004182 {ECO:0000313|EMBL:TNN20340.1};
OS Schistosoma japonicum (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6182 {ECO:0000313|EMBL:CAX74662.1};
RN [1] {ECO:0000313|EMBL:CAX74662.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX74662.1};
RX DOI=10.1038/nature08140;
RA Liu F., Zhou Y., Wang Z.Q., Lu G., Zheng H., Brindley P.J., McManus D.P.,
RA Blair D., Zhang Q.H., Zhong Y., Wang S., Han Z.G., Chen Z.;
RT "The Schistosoma japonicum genome reveals features of host-parasite
RT interplay.";
RL Nature 460:345-351(2009).
RN [2] {ECO:0000313|EMBL:CAX74662.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anhui {ECO:0000313|EMBL:CAX74662.1};
RA Gang L.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:TNN20340.1, ECO:0000313|Proteomes:UP000311919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HuSjv2 {ECO:0000313|EMBL:TNN20340.1};
RC TISSUE=Worms {ECO:0000313|EMBL:TNN20340.1};
RA Hu W., Luo F., Yin M., Mo X., Sun C., Wu Q., Zhu B., Xiang M., Wang J.,
RA Wang Y., Zhang T., Xu B., Zheng H., Feng Z.;
RT "An improved genome assembly of the fluke Schistosoma japonicum.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the proteasome subunit p55 family.
CC {ECO:0000256|ARBA:ARBA00006397}.
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DR EMBL; FN318934; CAX74662.1; -; mRNA.
DR EMBL; SKCS01000028; TNN20340.1; -; Genomic_DNA.
DR AlphaFoldDB; C1LIY4; -.
DR STRING; 6182.C1LIY4; -.
DR Proteomes; UP000311919; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR040896; RPN5_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18098; RPN5_C; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000313|EMBL:CAX74662.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000311919}.
FT DOMAIN 232..410
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 445 AA; 51881 MW; 4F7D4FBE0E6135EA CRC64;
MDGKIQHKME VDYSLSVDNL LASIKPLLTA GNFDSAIEQC ISLEKQTRTA SDAISTGRLL
EAIVEILAEN SQWARLNEHL ILMTKKHGQM KQAVSKMVQK AMEYLEKTPS EPIKLELIEA
LRNVTEGKIY VETERARLTK ELARIKESHG DIEGAAAVLQ DLQVETFGSM EKKEKVEFML
EQMRLCLAKK DFIRTQIISN KISTKFFADA ENEDLKLKFY NLMIDLNAHD SLYLNISKNY
WEIYNSKSIQ EDEQKRLLVL RHVIIYLLLS PYDNEQHDLM CRRKLVKDME KIPSYFDMLK
AFTTQELLKW DDFCKQYESA LRAETDVFSK KGDESESETR WCDLHLRVIE HNIRVISGYY
TKIRLNRLSQ LLDLDVDKTE EYLSKLVVNK TVYAKIDRLE GVVHFIAKKM PTEVLNDWSY
NTRNLMALIN QTTHLINKER MIYGV
//
