ID C1MH34_MICPC Unreviewed; 1626 AA.
AC C1MH34;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=MICPUCDRAFT_37808 {ECO:0000313|EMBL:EEH60677.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH60677.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH60677.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; GG663735; EEH60677.1; -; Genomic_DNA.
DR RefSeq; XP_003055425.1; XM_003055379.1.
DR STRING; 564608.C1MH34; -.
DR GeneID; 9680513; -.
DR KEGG; mpp:MICPUCDRAFT_37808; -.
DR eggNOG; KOG1144; Eukaryota.
DR OMA; VKWRAFI; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd02796; tRNA_bind_bactPheRS; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR002547; tRNA-bd_dom.
DR InterPro; IPR033714; tRNA_bind_bactPheRS.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR Pfam; PF01588; tRNA_bind; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS50886; TRBD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EEH60677.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00209};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00209}.
FT DOMAIN 319..429
FT /note="TRNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50886"
FT DOMAIN 1027..1248
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1339..1366
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 47..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1626 AA; 172957 MW; 618980FF08E777E1 CRC64;
MGKKGGKKGK GLPNLSDDED VPDPIAAGGG GGGGGGGGPK KNKKGKRRGD ASSDEDDAPP
AKAPPGKTAA AADDDDDAPA LSRAQKRKDK KNKKGGKGGG GGKGGFDDDD DDDDDLLALA
AMGGGGGGGG GGSDDSEDEP PAFKPPAKNN QKKGGKGGGG AAGFAALMGG DSDEDASEPE
PEPESDSDGD AAPARGGGGA AAGFAALMGG DSDEDDDGAE EELEPEPEPE PEPEPEPEPD
VLVKKKKKKK GGFDALALED DEPEPEPEPE PEPEPPAAPP AGDDGSDDEP LLLVKKKKKK
KPLDLSALTG EDEPAAAAAA AEPGLIIAEV TECAPHPMAD KLTICQVDVG DGEPLRVVCG
APNVRAGLKV IFARVGVVVP STGAKLAKTP LRGVMSEGMI LSAAEMGWMP KAVGIIECPK
KAPVGEPAPL DPPPDLAMAD PAAKKKKSKD KDGKEKKEKK EKKEKERERS PTQEAEAEAP
PAELVLGKKK KKKAAPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPTAKE EKTKKKKKKG
GAKEEEKTGD DDLDALFAEL GIEKKEEDAG GGESKAAKKR REKKEREAAA AAAAAAGEGG
GAAADGADDG GAAGGAEEGE SVWEKQLEEL EALQASGEKL NDSQKNKLKK LKKKAKEKEA
KDAKGGAPGS GSKSGAGKPS AAVLRMQEQI RLREEAEAAA AAAEAERIAQ EEAEEAAAAA
AAAEAEAKRL AKKERERLKK EQLKKEGKLL TGKQKEEQRR LEAMRAQILQ NSGSSGNLAA
DDDGDGELRR SVVVDDRKKK KELFEQRKAE AIARKAAEEE AAIKKLQEDK AAAAAAEAAA
KAAAAAEESD DAEDDWDAVD DLDALVKIPN KAEEERKAKE AAEREAARLA LDAEKKRKAA
EEAKAAKATA KPAPGSGGKG EKPWAAAARA KAEAAKAANA EASDSDSESG SDSDASGSDS
DASGSDSDSD SDSDSDSSDY SSSDYTSSEE DSDDERERLH REKMQVAKTA RLARFEAIKA
ARSADRLRCP IICILGHVDT GKTKILDNIR RTNVQDGEAG GITQQIGATF IPDTAIRDRT
FQLNKGELKL DVPGLLVIDT PGHESFTNLR SRGSSLCDLA ILVVDIMHGL EPQTLESLNM
LRMRKTPFII ALNKIDRMFD WDAKADFPTR ETLALQKQHA RAEFEDRAKK VMLEFANEGL
NAAIYWDNPD VRKFINVVPT SAITGEGIPD MIHTLVDLTQ TRMNERLRFF DAVQCTVLEV
KMLEGLGTAM DVILINGTLR EGDTIVVAGL QGAIVTTIRA LLTPQPMREM RVKANYVHHK
EISAAMGIKI VANGLEQAIA GTSMLVQNKE DDLDELKDEV LSDMKNVFSR VDKSGEGVYV
QASTLGSLEA LLEFLKSDAV KIPVAGIAIG PVNKRDVMGA SVMHERKRPE FATILAFDVK
VTEEATRMAN ELNVKVFTAD IIYHLFDQFT AYMAEIKAKK KAAAAEHVSF PCVLKIMPNC
IFNKRDPIIV GVDIVKGIAR IGTQLCIPSQ GFIDIGKIAG MERDHKQVDK ATPGQSVAMK
IQPVSAAESS RLYGRHFDHK DELVSRITRE SIDMLKENFR DELGKEDWRL VVELKKKFEN
HYGEPM
//