ID C1MJL3_MICPC Unreviewed; 1121 AA.
AC C1MJL3;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=ATP-binding cassette superfamily {ECO:0000313|EMBL:EEH59215.1};
GN ORFNames=MICPUCDRAFT_55005 {ECO:0000313|EMBL:EEH59215.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH59215.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH59215.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
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DR EMBL; GG663736; EEH59215.1; -; Genomic_DNA.
DR RefSeq; XP_003055839.1; XM_003055793.1.
DR AlphaFoldDB; C1MJL3; -.
DR STRING; 564608.C1MJL3; -.
DR GeneID; 9681273; -.
DR KEGG; mpp:MICPUCDRAFT_55005; -.
DR eggNOG; KOG0054; Eukaryota.
DR OMA; ICINIPV; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF443; MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:EEH59215.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..386
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 503..728
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 854..1098
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT REGION 746..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..803
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 123682 MW; B5F5A03E4F505144 CRC64;
MLKKSHGGDD EKGRQVVSAA DLEPVRWIKP NVFQQLVFAQ ATPLISRGQV RRLEPHDLCR
LPEMESQALW HAFERDWAEE RERNPDNPSL VRACLKGSRP TFVGTGILYA IAQASLFSGP
VLLQQIVKAI EENGGDGCAS TRQMYIYGMI LTLAGVLQSF CQAQSDYALQ RLGVRVRNRL
MCALYRKCLK LSPKGLQARS EETTGKIVTL MSNDVNKLQD VFQLLHNLWC APIFIVAAFA
MLYLIIGWSA FVGFLCILVA APLTFKVAKT LFMIRFKLVK CADRRVNILS EVINGMRVIK
YYAWEKAFKA RVDKIREEEV KLIWASQKVG ALFGVALFST PVFIAVCSLG SYSLAGNDME
ASTVRRRVFV FVFVFVFVFK FVSFLFVSCR SFAYTALALF NMLRFPLIMV PFLLTTLLNA
LNAVDRLGAF LLQDESDDLE RDASEPGRVV VTNGRFAWPK VPKKTEAPKF PPGPQGRKMK
KAWEAEQKAK KTAEDEARAE AEAKGEEFIV DTDEPEQPPF ELGGVDLDLK PGSLTMVIGR
VGSGKSTFLS GLNYFVPRVE GEMKVSGSVA YVAQQAWILN STVRENILFG KPYDEEKYQK
TIAACQLEQD LDVLPNKDFT YIGERGVTLS GGQKQRVAIA RAVYASADVY LMDDPLSAVD
NHVGAALFEK VIAGSFMKKA TRVLVTNALQ YLPKADSIVV LDDGEVVDVG TYKELMAKGL
DFATLMAAHG VGAFYLTLVP VRPHDDEKKR ASQDGGSGRP STDGRKSSVG SRPSVDGKSP
RSPTAAAAKP GPPIAPPPPG RPGKKEDMNV EEERAVGHVS GAVYGALYRA TGSKFSVPVM
VFMFAMEYGS KATLDYWLSR WAADSYGWES NRYLGVYFAI FVFNGIAIFL RSLFIYFFLV
RAAKNMHDQL IGRVMKFPMA FFDTTPSGRV INRFSRDTET IDIILPGIII QFLGCIASIC
TTLAVVCAAT GWFTLAIPPI VFMYVSIQRF YIPACRELQR IESISRSPIY SGLGEAVNGV
ETIRSFGAEK HFISTSDGLV QHNADAYVTQ KLGSGWLGTR LRFLGTLIVA CTAFLVIQGS
RAGTVSAGVA GLCLVYALDV TKARPVRWSP YDPVGVVKAD P
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