ID C1MJR4_MICPC Unreviewed; 936 AA.
AC C1MJR4;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=MICPUCDRAFT_38354 {ECO:0000313|EMBL:EEH59242.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH59242.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH59242.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; GG663736; EEH59242.1; -; Genomic_DNA.
DR RefSeq; XP_003055866.1; XM_003055820.1.
DR AlphaFoldDB; C1MJR4; -.
DR STRING; 564608.C1MJR4; -.
DR GeneID; 9681635; -.
DR KEGG; mpp:MICPUCDRAFT_38354; -.
DR eggNOG; KOG2108; Eukaryota.
DR OrthoDB; 5490899at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 308..546
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF00580"
FT DOMAIN 822..917
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13361"
FT REGION 285..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 99934 MW; 942CA956F9FDD70D CRC64;
MDAAAAAAAD ARGHDTVAVT RATLRRDPRA RGVAPSAPLE VALTLDYDGT STVAAAAAAA
LRTRLVAGAP KGVERQLARA RAGEGKKRAR EATRQGSLVD AFARQSVAAL VAALERAEEK
DGSAPRVGAG LAAAVEEVST WRLCGGSGGL GDGGGECHVS GRHVSGRRHV GARGGDAWAT
LACAFFACAE DSRAIATLFA AAVDAARLTA TTEDGTSTDA VEDVTELTSL VAAAAGCEAS
WRGNREAARA KLTQLEIAEA YAEIAQKPPP RALTREQRAI VAAELTGAGG GGGGGKNPHP
RDRRRPPRTM IVSAFAGTGK TSTLIEYARR RPGYAFAYVT FNRAVCEDAK TRFPGNTTCV
NFHSLAFRKC GFQYQNTPGK LLRGTLRPSH AAAALNHHLN HRGTGTAAEK IASTDDRLAL
ALRTLNAFLI SEDDAVDATK HVPPKREWVA TTRPANTHAA RREVKTSSEE LASFATTLWD
AMKDKGNATM PMTDAGLDYD YDVIMLDEAQ DASPVMWSVV KNQDACGKIL VGDPNQEIYG
FAGAKNAMDA AAAATPAEHL TRRTLSVSFR FGPEIASVAC SLLALKGSAD AVVGARRADV
DEEAGGEVAA DAAADAAAVR VATAPISLIK TFIPPLTTHA PSDAPSDAPS APAASLARPR
KKKREQLVVL CRSNGSMFDV AGQVAEVVAE EDDNFHDVIF PDWKPSANPK IAFVGGEEAL
RLDQLVDVWR LAFGDLDDLH RVDDKYVRTF ARRLVEDSGY PFHHPEWTRD VDKRLEGLAR
ATAAQRDAEM SSKIAIVRRF GKRLPERVRA IRRATVPDRD DAHVVLSTAH KSKGLEFDTV
LLWDDFVDVG AVRATTTTTT TTSTNVAAAT RFTVPIHNAQ GGNEFGFDFE EEEDVDPDEI
NLVYVAATRA KKRLYLVRSI SRWSPYDRVR VVNAVT
//
