ID C1MLP6_MICPC Unreviewed; 1702 AA.
AC C1MLP6;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=MICPUCDRAFT_25361 {ECO:0000313|EMBL:EEH59576.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH59576.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH59576.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; GG663736; EEH59576.1; -; Genomic_DNA.
DR RefSeq; XP_003056200.1; XM_003056154.1.
DR STRING; 564608.C1MLP6; -.
DR GeneID; 9681813; -.
DR KEGG; mpp:MICPUCDRAFT_25361; -.
DR eggNOG; KOG0985; Eukaryota.
DR OMA; HCYDLLH; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 345..366
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1702 AA; 190935 MW; ADAF0B70BC220077 CRC64;
MATPPITVKE IVSLTSCGIN PQCISFTNLT MESENFICVR ETGVANSVII VDMASPAQPM
KRPITADSAL MNPVSKVIAL KAAVAGTTQD HLQIFNIEMK SKMKSHQMPE SVEFWRWISP
DMIGIVTNSS VYHWSMEGDA APRKMFDRTE NLAGNQIISY RASEDMQWFT LVGIAPGNPA
RPALVKGNMQ LYSVAQSRSQ ALEAHAAAFA THLVAGNTAK SHVVAFAQRM VQPDGSISSK
LHVIELGAQA GQSPFQKRQA ELFFPPDFVD DFPVSMHISE KYGVIYVVTK NGLLFVYDLE
TATAVYRNKV SNDPIFIACG SPSSGGIYVV NRRGQVLLIN LNEPAVVPFI SGQLSNVELA
MSLAQRGNLP GAEALVTPKF ELLFSQGDFK AAAELAADSP KGALRTRETI AKFQAVPAQP
GQNSPLLQYF GICLQRGKLN AFETLELSRL VLSQNKKVLL DTWMAEDKLE CSEELGDMLQ
NVDPDMALRV WIKARANNKV VATLAGKGEF EKMGKYCEMA NFKPDYSYLL QSTLMSNPQG
AVNIAIQIGN QSPPPLDFNA VADLFLQRNM IREATSFLLE VLKKDLPEQA ALQTKVLEIN
LVTFPNVADA ILGQGKLTHY DRPRIAQLCE KAGLYMRALQ HYVEVSDLKR CCVNTHSIDP
AALIEWFGTL SREWALECVK ELLISNQRQN LQIVVNVCKE YTEQLTADSI ITLLEEHKSA
EGLFYYLGSL VATSEDPDVH FRYIESAAKT GQIKEVERVT RESSFYDPEK AKVFLMEMDL
PDARPLINVC DRFDFVPELT THLYQKKLLR YIEGYVQKVN PSNAPLVVGA LLDQECDEDF
IKNLILSVRS LLPVGPLVEE VGKRNRLKML TPFLEHLVSE GSTDPSVHNA LGMILIDSNS
NPEHFLTTNE HYDSKVIGKY CEKRDPNLAC VAYKRGNCDF ELVDCTNKNS LFKLQSRYVV
ERMDHDLWAH VLNDENAHRR QLIDQVVSTA LPESKNPEQV SVTVKAFMTA EMPQELIELL
EKIVLQNSAF SNNPNLQNLL ILTAIKADKT RVMDYVNRLD AFNGPEVGEI AVGNELYEEA
FAIFKKFDLH VDAMKVLLDS IESIDRGSEY AAKVDLPDVW SQLAKAQLAL DVGAAVASYI
KAQDGADYNA VIDVAKKCND YEALVKYLVM VRKKVKEARV DTELCYAYAR INSLGELEEF
IMTPNAASRE TVGERCFSEG LYEAAKVMFT ADSNWARLSS TLVKLLRYQE AVDAARKANQ
TKTWKEVCFA CVDCEQWRLA QLCGLQIIVQ ADELEEVSLY YQSRGRFPEL LSLMEAGVGL
ERAHMGIFTE LGILYARHRP EKLMEHLKLF STRINIPRLI RSCEEMAAWK ELSFLYIAYD
EYDNAAGVMM EHPDAWEHVS FKDVCVKVAN VEVYYKALNF YLQDHPTKLN DLLTVLTPRI
DHTRVVDLMR KAGHLPLLKP YLSAVQNCNL NAVNDAVNEL CIEEEDFQGL RNSIDLYDNF
DQMSLAFRCE KHDLLEFRRI ASYIYQKNLR WKQSVELSKK DRLFKDAMEA AAQSGDRTIA
EELLNFFVAD RNRECFAACL YTCYDLLRAD IVCELAWTNG LIDFAMPFMI QVLRDYTGKV
DSLVEDKKDR NDERVAAEKE AVEQQMNQNL YAQLLPAALP APGMDSTGGT FVPGTIPPRG
MAGYGSDSIS PGGYMPQQQG YF
//
