ID C1MMU2_MICPC Unreviewed; 393 AA.
AC C1MMU2;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EEH58634.1};
GN ORFNames=MICPUCDRAFT_15406 {ECO:0000313|EMBL:EEH58634.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH58634.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH58634.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; GG663737; EEH58634.1; -; Genomic_DNA.
DR RefSeq; XP_003056989.1; XM_003056943.1.
DR AlphaFoldDB; C1MMU2; -.
DR STRING; 564608.C1MMU2; -.
DR GeneID; 9682903; -.
DR KEGG; mpp:MICPUCDRAFT_15406; -.
DR eggNOG; KOG1526; Eukaryota.
DR OMA; LMCPDGR; -.
DR OrthoDB; 423at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR004790; Isocitrate_DH_NADP.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 2..389
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 393 AA; 43410 MW; F9A6C60DD979A863 CRC64;
MVYVAGEEMT RYTMQLILDK WVSPHVDTSR WEFFDLRAKN RDDTEDQVLR DVITAGARLK
AIFKEPTITP TADQVKRLGL KKAWGSPNGA MRRGWNGITI SRDTIHIDGV ELGYKKPVFF
ERHAVGGEYS AGYKIVGKGQ LKTTFVPEGG GDAIVVDDRA VVDDLNAVVT YHNPLDNVNH
LARIFFGRCL DAGIVPYVVT KKTVFKWQEP FWETMKRVFD DEFKEKFRAK KIIGDNAELV
HLLSDAATMK LVVWTDGGFG MAAHNYDGDV LTDELAQVHM SPGFITSNLV GVDADGTLIK
EFEASHGTVT DMDEARLRGE ETSLNPLGMV EGLIGAMNHA ADVHGGADAV HPYTAKLRAV
IHKLFREGRG TRDLCGAGGL TTEQFIDAVA AEL
//
