ID C1MPA2_MICPC Unreviewed; 818 AA.
AC C1MPA2;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Histone deacetylase {ECO:0000313|EMBL:EEH58430.1};
GN ORFNames=MICPUCDRAFT_38694 {ECO:0000313|EMBL:EEH58430.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH58430.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH58430.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
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DR EMBL; GG663737; EEH58430.1; -; Genomic_DNA.
DR RefSeq; XP_003056785.1; XM_003056739.1.
DR AlphaFoldDB; C1MPA2; -.
DR STRING; 564608.C1MPA2; -.
DR GeneID; 9682689; -.
DR KEGG; mpp:MICPUCDRAFT_38694; -.
DR eggNOG; KOG1343; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR OrthoDB; 69755at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd11599; HDAC_classII_2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT REPEAT 63..89
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 127..159
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 257..639
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 35..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 684..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 43..59
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..818
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 87772 MW; 7E64C84B33FE425D CRC64;
MFGSDSDDDE ITGQFALHDA AEAGNAELIA KMLGKEKKDG EFNPEEEEDD DDDDVDVNET
DRDGCTPLHV ALFNSATECV KLLLENGAES WITVEGSPAL HVAYPTTEQL NTGDEDQPDP
INARDKLGWT PLHHACYGGH ADIVNKLLAR GSKPGKVTKA GLTSLHAAVV GRNVAAVTAV
MNAEPSILNN ACNDEKTAVE MADARGYPLI AAVLRGEDTS AVETPPPPPP PVIIAPDECF
MHHSCPPITR DGRDPPPENV NRLQVLLNKK TGILRAAEFS NVDIVSEVRP ATMADVLRVH
EYPYVRKIQK ICERIPDWNS NPNGALGTID GDTEVCHSSF SAALCAAGAV VEAVDRVVAG
SAEKVFCAVR PPGHHAGPNG PVPAPGDPIG SGSHGFCLLN NVALGAAYAR CVHRHSLRRV
AIIDFDVHHG NGTEAVVQNT TPAAPKFNFS TPYCEGAITV PTYRPWLDET DHEEVFFASV
HGYGRARGFN FYPGSGPTDD TRHVGDYLTT EEAAQWNEEG VVDDPYHVAT AKSDSTAQGP
TPWVVDVGME GTGKKAERGA AWRRVWRGKT LPAIAAFKPD LVLISAGFDA HAKDDIQGPV
NLGVKEADYE WLTEELCKIA NTCCQGRVIS VLEGGYRIQG GVVSAFGRSV ASHLRAMFRE
NREGWSAEQC QKELDIELKQ RRLAKEADEA KRAAAMEAAR QREEAAIAAA QAAMEAAGGD
GDEAEAAAAA AAAAVLGDEA PTKRRRKAVD YTQLNAELEK ESNPAAAEAE EPAAEAEEPA
AEAVEEEGEE DVEENGEELE MEDEDGGEEL EEDLEMEE
//
