ID C1MR96_MICPC Unreviewed; 1823 AA.
AC C1MR96;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Dead-box like helicase with PHD domain {ECO:0000313|EMBL:EEH57845.1};
GN ORFNames=MICPUCDRAFT_57576 {ECO:0000313|EMBL:EEH57845.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH57845.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH57845.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC FANCM sub-subfamily. {ECO:0000256|ARBA:ARBA00009889}.
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DR EMBL; GG663738; EEH57845.1; -; Genomic_DNA.
DR RefSeq; XP_003057894.1; XM_003057848.1.
DR STRING; 564608.C1MR96; -.
DR GeneID; 9683702; -.
DR KEGG; mpp:MICPUCDRAFT_57576; -.
DR eggNOG; KOG0354; Eukaryota.
DR eggNOG; KOG0383; Eukaryota.
DR OMA; GWGATQD; -.
DR OrthoDB; 12149at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd18033; DEXDc_FANCM; 1.
DR CDD; cd12091; FANCM_ID; 1.
DR CDD; cd15568; PHD5_NSD; 1.
DR Gene3D; 1.20.1320.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039686; FANCM/Mph1-like_ID.
DR InterPro; IPR044749; FANCM_DEXDc.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EEH57845.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 343..514
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 689..913
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1778..1823
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 24..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..57
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1558
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1584..1601
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1605..1628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1663
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1823 AA; 191649 MW; 177AE9F0599D5C0C CRC64;
MPFEIADDWD DDALMGVDVD AIAAARTSAP PAGPSDRDPA PGHRPAPRQP PPATHHHRPQ
QQPNRATAAA PPRQRHPPPQ QHFDGGGGPP HPANEGFSGH TGYKGGFSGH GGGAQQGGRQ
GWQRQRGGGG GGARWNASDA NHRTGHDAVD RALASNAPRF TANNQPPVNQ RTVTTMFAAK
GGPKQTLFRP GVEEKQRTLD SMFGGSGGRG GGGGGGGGGD GDGDGGSADV LPHQRPIEID
GDGDAWWSAP PPVAAAAAAA PRRQAPAAVH HHTHPSKWQP SQHVASTPEG QYAGRLTPSA
MGTPNSQGLI RCSDANGMLL DPHAAQSYVY PGQLVRRDYQ YNITRDALTT NSLVCLPTGL
GKTLIAAVVM YNFYRWFPKG KVVFLAPTRP LVDQQKAACR DICGIPENDI CVLMGSTKKD
ESGTRRAFWD QKRVFFCTPQ TMENDIASSV LPAKDVVCLV IDEAHRAKGK HAYCGVVRML
WDRNVSFRLL ALTATPGHDI ADVQQVVRNL NIGRIDFRSD KDVDVKRHTH NRSIQLESVK
ATRAISEVQD MLRDVLRPML KTLTSMGALP TEGVKMARFV EGTSKDIPQP FTIQLAQRDL
QNGNTAVPPA KKNYAFSLCL QSYFIARLNA LLSGYSAQQA VDYVEDQNTK GYIGALFGAS
PVMREVLDML RSMAGHGAHH SPKLARLTQI IRRHFATNNP ATRAIVFTSY RDSVRDIVRA
LREVTVTTGG GNNLGPGDPL VDPEKGQKTV TGMFSAASGS GGGSGDTAGV PPEVPDGAEC
RIKVAEFIGQ GDSSKGGGGG GAKGAGAARG TKGQSQKEQK AVLDAFRHGS LNTIVATSIG
EEGLDIPAVD LIVFFDVVDT IRTIQRMGRT GRARDGKVVV LALEGREAEK FSKEQGKYEH
LLRSLSDPGR CFQLCNDCPR MLPAGLDPRC ELKELGPTPE ALKAKREMEA RGSSGKKRKG
ARGGAGRGNA SAFSIRPWDA PLTTVEHSLL QAYDCAPRAM GRIDMQNAAP LQRRPTPVFS
VPHGRMCVAL MRAMSAAQGL PPPLDVRGES IEGGAIAREE KAKADAEAAR DRAHAEANAD
APTTAFYAPP VEWDDDEWGD GGFVPAAFDD DVGGGGIDDD DEPLRANWDS QRSHGYEAPI
LDASAVKDDG PRASVSQAPT ELDERAACEY DDDDVTRSID ASGSHGGFNG VGGGGAHTGA
TQRLDFTATL VDPSPRRVVA NEAEPCENPE CAVIGCDDPK HGASRNDRTP LAQLTPPSQR
PGSNAMNTQG ASVHGDPLCG EENDDVFATA PAPVARPSPS AAESARQRLR ERLSQQSQQQ
RAHSQSQSQS QLRRQNTTQP EAQADVPDDD DETIADIAFH IKQKKLAAAA KKRATASAEK
AAKASASKSK SKSVSASQMP PPPPRATVRE ASTPGFDVAP TVDDAVTPGA ADGWWGTGDA
QDDAVGGWGG TQSGGGGGGG WGVSQNTQTS GGGWGAPATQ DDAGVGWGAS QGTQDSAGGG
WGGVSDAGGD AGWGGGSPSQ NDDDAEGGWG DPPDENDARG GAPGTDPPPA PPASTPVQPT
PDSDDLMVLK RRKRVAAPAP SPAVEPVRRR PPPPPPPSFA PAGDDDDDDG WRRGGATKRA
DVLAAKRTKR ANAAKQAAVH RFMDDVASGD DDDDDDDDGW NTEDEAFVAA TQGDALDASG
DEPALMHQQL ALLADAHTPL DVAGVVGRRF GPRVRRDVAD TPPGTTPGTG RSGGGGGDAA
SQYGGSWIDD DEEATVLETQ FGDDDDASGE LLGSDGNMER CARCERGGVL VCCDACPGAY
HLACVGLAET PPGAWLCPAC ERR
//
