ID C1MRE5_MICPC Unreviewed; 632 AA.
AC C1MRE5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=MICPUCDRAFT_16051 {ECO:0000313|EMBL:EEH57863.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH57863.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH57863.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SUBUNIT: Heterotetramer consisting of two non-identical subunits: a
CC beta subunit and a large alpha subunit.
CC {ECO:0000256|ARBA:ARBA00011653}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
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DR EMBL; GG663738; EEH57863.1; -; Genomic_DNA.
DR RefSeq; XP_003057912.1; XM_003057866.1.
DR AlphaFoldDB; C1MRE5; -.
DR STRING; 564608.C1MRE5; -.
DR GeneID; 9683733; -.
DR KEGG; mpp:MICPUCDRAFT_16051; -.
DR eggNOG; KOG1223; Eukaryota.
DR OMA; GCVGYLD; -.
DR OrthoDB; 705at2759; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR005256; Anth_synth_I_PabB.
DR InterPro; IPR015890; Chorismate_C.
DR NCBIfam; TIGR00564; trpE_most; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 127..277
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 340..614
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 632 AA; 68155 MW; C68F117EB50657DD CRC64;
MACIIGATQA AHAAASASSR GSRGPSAATA ATTRVAAANG EKILRKNRPS LAASVPSHGS
SSARRVATAR AIADGPAPAA APAAASAASA ASAAKRAAPR STQADEFRAL VGAGHNLVPL
YRRIFDDQLT PILAYRCLVK EDERDAPSFL LESVVGGTQT GRFSFLGSRP YLEVIAKESS
CVVLDHHAGT KTRSTESDPM AVAQQIATKW HPTRTEGLPE CFTGGWVGYT GYDTVRYQYL
NKLPFGDAPT DDRALPDLCL GLYRDVVVFD HATKQVYAVH WVDTTVFGGD VEASLEDGER
CLHDLVKALQ PSSAPTLPFG EVSMSLTAPP TPPKDSTMTK EAFLNAVAET KEHIVAGDIF
QLVLSHRFQR STFADPFEVY RALRVVNPSP YMIYLQARGS IIVASSPEIL CRTDKHRTVV
NRPLAGTRMR GKTKEEDDAL ELDLLADEKE KAEHVMLVDL GRNDVGRVSK AGTVKVEKLM
EIERYSHVMH ISSTVTGSLL EDLGPWDVLK AALPVGTVSG APKVRAMQII DELETTRRGP
YGGGVGYVGF MGEMDMALAL RTMVIPTEHK ENLYEFRNGI EGKSRREWTI HLQAGAGIVA
DSNPESEYQE TVNKAAALGR AIDLAEEAFE DV
//
