ID C1MUL3_MICPC Unreviewed; 555 AA.
AC C1MUL3;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 03-MAY-2023, entry version 59.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE Flags: Fragment;
GN ORFNames=MICPUCDRAFT_27276 {ECO:0000313|EMBL:EEH56647.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH56647.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH56647.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
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DR EMBL; GG663740; EEH56647.1; -; Genomic_DNA.
DR RefSeq; XP_003059515.1; XM_003059469.1.
DR AlphaFoldDB; C1MUL3; -.
DR STRING; 564608.C1MUL3; -.
DR GeneID; 9684955; -.
DR KEGG; mpp:MICPUCDRAFT_27276; -.
DR eggNOG; KOG1157; Eukaryota.
DR OMA; ANIREWQ; -.
DR OrthoDB; 1396at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR43061; GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR43061:SF1; GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 31..131
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 405..464
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT NON_TER 555
FT /evidence="ECO:0000313|EMBL:EEH56647.1"
SQ SEQUENCE 555 AA; 60950 MW; 5307A5E794AD6C7B CRC64;
MDALERDEVR AAVAVAHDAH DGQRRKSGEP FVTHPVAVAG ILADQRMDHE TVIAGLLHDT
VEDTDLVTFE SIQERFGAAV RRIVEGETKV SKVSSSTKAN VQADDLQQMF LAMTQEVRVI
VVKLADRTHN MRTLWSLKPD KRRRIAQETL LVFAPLAKLL GMYKVKNELE ELAFMHVAPE
QHAITSRWFD ELSKRQEPVV TRAAAELQKM CDEDDFLKSA CERVEIQCRA KELYGVYRKA
GGERIPTAPP GSDAERESLE LLSSRLRRAL TSRLCYHVLG IVHAAWPPVP GRMKDYIATP
KLNGYKALHT VVQPIGGGAK RGKWGEGGGD EVFPLELQIR TEDMHRMAEC GIAADKEVKA
AVLIKSGHER QLAWLANIRE WQEEFLGVLT AEEFVDTITG DLLGRRVFVF TPEGGVMNLP
AGSTVVDYAY YTDVGVDMIA AKVNGVDVDA DYRLSNADVV EIIATENSGL ELFAGAGEAS
ASAVARAVAK QKVALQKGFF DIAKTRSAKY KIQKFLAENG DVPRTTAPAL GAVSAAAPNS
EVDVILNGAR NDVVR
//
