ID C1MYL6_MICPC Unreviewed; 463 AA.
AC C1MYL6;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=rRNA methyltransferase 1, mitochondrial {ECO:0000256|ARBA:ARBA00034881};
GN ORFNames=MICPUCDRAFT_59944 {ECO:0000313|EMBL:EEH55065.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH55065.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH55065.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; GG663742; EEH55065.1; -; Genomic_DNA.
DR RefSeq; XP_003060296.1; XM_003060250.1.
DR AlphaFoldDB; C1MYL6; -.
DR STRING; 564608.C1MYL6; -.
DR GeneID; 9686027; -.
DR KEGG; mpp:MICPUCDRAFT_59944; -.
DR eggNOG; KOG0838; Eukaryota.
DR OMA; EGANTHA; -.
DR OrthoDB; 5404245at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0031167; P:rRNA methylation; IEA:InterPro.
DR CDD; cd18105; SpoU-like_MRM1; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR047182; MRM1.
DR InterPro; IPR047261; MRM1_MeTrfase_dom.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR46103; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46103:SF1; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001876};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 188..276
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 20..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 48414 MW; D48CA9385BABB482 CRC64;
MTRVATLPGA LLRLNLRCLR PSGGGRVAAS RAPLAARRAP ATTTTSVSSW RMGGGGGEGR
TTEEPPPRSS PPSSRDRYGY GDDDPSDFED DGPRPGRRGG GGGGGGGRGA GRRGGGFANN
NSHADRRNPY YTAESSSSSA PRGGRRSRDR GATHDADAQP RTVWQERHDE KKRNRAEPTL
AERMTGEALY GLNPARAALR DAARRARAGA AARRTIYRMF VQEGSDASGD AALLRAARDA
RVEIETVSKH DLNVLTGSPP RPHNGVVLDA SALTPTPIDQ LPRWVHGEGS STVKGPAPVW
LALDEVVDPQ NLGAVLRSAK FLGVAGVVVC AKNSAPLSPV VSKASAGALE SMDVRSVGVM
HRFLMRCVED GWDVYGTAAE EGAADVADVD ARGRPSVLVM GNEGAGLRTN VRRACTSMLR
IAGGGGEGDD DDGVDSLNVS VATGVILHAM LTSARRAPAV AEE
//
