ID C2EUN9_9LACO Unreviewed; 653 AA.
AC C2EUN9;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Glycoside/pentoside/hexuronide transporter {ECO:0000313|EMBL:EEJ40366.1};
GN Name=gph {ECO:0000313|EMBL:EEJ40366.1};
GN ORFNames=HMPREF0549_1175 {ECO:0000313|EMBL:EEJ40366.1};
OS Limosilactobacillus vaginalis DSM 5837 = ATCC 49540.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Limosilactobacillus.
OX NCBI_TaxID=1423814 {ECO:0000313|EMBL:EEJ40366.1, ECO:0000313|Proteomes:UP000004483};
RN [1] {ECO:0000313|EMBL:EEJ40366.1, ECO:0000313|Proteomes:UP000004483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49540 {ECO:0000313|EMBL:EEJ40366.1,
RC ECO:0000313|Proteomes:UP000004483};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC sodium:galactoside symporter (TC 2.A.2) family.
CC {ECO:0000256|ARBA:ARBA00007724}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ40366.1}.
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DR EMBL; ACGV01000133; EEJ40366.1; -; Genomic_DNA.
DR RefSeq; WP_003716443.1; NZ_GG693412.1.
DR AlphaFoldDB; C2EUN9; -.
DR STRING; 1423814.HMPREF0549_1175; -.
DR GeneID; 75083094; -.
DR PATRIC; fig|1423814.6.peg.1501; -.
DR eggNOG; COG2190; Bacteria.
DR eggNOG; COG2211; Bacteria.
DR HOGENOM; CLU_027408_1_0_9; -.
DR OrthoDB; 9764596at2; -.
DR Proteomes; UP000004483; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR CDD; cd17332; MFS_MelB_like; 1.
DR CDD; cd00210; PTS_IIA_glc; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR018043; Na/Gal_symport_CS.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR NCBIfam; TIGR00792; gph; 1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11328:SF36; MELIBIOSE PERMEASE; 1.
DR Pfam; PF13347; MFS_2; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 517..621
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
FT REGION 477..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 70925 MW; 9FD12CD317D255DC CRC64;
MNNSSKSQEH VGRARFAYSM GAFGHDAFYA LLSTYFIMYV TGHLFHSGNK AFNDHMILWI
TTIIAVLRII ELLIDPMIGN AIDRTHTRWG KFKPWVVGGG IISAVILAAL FTPLGGLNVS
SPYLYLIIFA ILYIIMDIFY SFNDVGFWSM LPALSFNSHE RDKIATFARV GSTVGGQIVG
FVIMPMVLFF SANQNGGTGD DRGWFIFAAI IAAIAAITAV GVGLGTHEQQ SLLRENKEQT
KLKDVFKVLV KNDQLFSIAM SYLFYTTGIT LVNSMELYYF TYILGNAKAF SILGGLNTVV
GVISVLTFPM FTNKISRRKL FYGSVSMLAL GLLVFAFAGH SLVMVLIGAE LFFIPQPLVF
LVVLMTITDS VEYGQLKLGH RDESLTLSVR PLLDKFAGAV SGWIIGPTAI AAGMTAGATA
SSLSASGVTT FKLVMFLAPA IMLAISVIIF ATKVKLDEKM HAKIVDELEQ TWGKQFTKGN
SNEADSTDET VAAPKPGVTE IPAPVAGTVV DLKNVSDPAF ASGSMGQGFA IKPSDGKVYA
PFSGTVRATF STRHAVGLVS DSGIALLIHV GIDTVKLHGT GFVTYFHKGQ HVTKGDELME
FWDPTIKKAG LDDTVIVTVT NSEEFDFKQL IPANQEVTTT DNVMEVTKKD QEK
//
