ID C2KUC0_9FIRM Unreviewed; 532 AA.
AC C2KUC0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Orn/Lys/Arg decarboxylase, major domain protein {ECO:0000313|EMBL:EEJ52636.1};
DE EC=4.1.1.19 {ECO:0000313|EMBL:EEJ52636.1};
GN Name=speA {ECO:0000313|EMBL:EEJ52636.1};
GN ORFNames=HMPREF6123_0089 {ECO:0000313|EMBL:EEJ52636.1};
OS Oribacterium sinus F0268.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=585501 {ECO:0000313|EMBL:EEJ52636.1, ECO:0000313|Proteomes:UP000004121};
RN [1] {ECO:0000313|EMBL:EEJ52636.1, ECO:0000313|Proteomes:UP000004121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0268 {ECO:0000313|EMBL:EEJ52636.1,
RC ECO:0000313|Proteomes:UP000004121};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC {ECO:0000256|ARBA:ARBA00010671}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ52636.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACKX01000012; EEJ52636.1; -; Genomic_DNA.
DR RefSeq; WP_007157624.1; NZ_GG668535.1.
DR AlphaFoldDB; C2KUC0; -.
DR STRING; 585501.HMPREF6123_0089; -.
DR eggNOG; COG1982; Bacteria.
DR HOGENOM; CLU_025925_1_1_9; -.
DR InParanoid; C2KUC0; -.
DR OrthoDB; 9815233at2; -.
DR Proteomes; UP000004121; Unassembled WGS sequence.
DR GO; GO:0008792; F:arginine decarboxylase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR43277; ARGININE DECARBOXYLASE; 1.
DR PANTHER; PTHR43277:SF3; LYSINE DECARBOXYLASE; 1.
DR Pfam; PF01276; OKR_DC_1; 1.
DR Pfam; PF03711; OKR_DC_1_C; 1.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EEJ52636.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000004121}.
FT DOMAIN 15..304
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 423..501
FT /note="Orn/Lys/Arg decarboxylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03711"
FT REGION 389..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 60435 MW; E89F69BAF967BBC1 CRC64;
MKDKSKEGRN LSASPLEKYF QHYNEKNLLP LHMPGHQRKR DMGTALPYAY DYTEVEELDN
LHAPEGILQE AMNRTAAYYG CSDCFYLVNG SSSGLQAGIF TLLEEGDEVV VARNCHRSVF
YALSLRKAKI HFLLPEFWED FSCFGSISPK EVERLLREFP KSKALIFTSP SYEGVVSDVE
AIARLCHENG LSFLVDEAHG AHFSPKKGAS FPESAISLGA DLVVQSPHKT LCSLTQSAWI
LGNGQRYSRE KLSFYLSVFQ TTSPSYPLML SLEKATTLLE REGEALFFHW KEVMESFREK
ARTLSYFTFL WEKEEACFAM DCTKIFLRAR GIPKLRLGKD LAKLLREDYG IESEMHSGEN
LLLMTGPFIS EEDMDRLFLT LKDIERRLGD EKRQKPGDER RKQAEEERGK QAEEERGKET
GDEMSELIEG SAQSLQSKIL SSALYQISIA DNTLQITEGL KEGEELNLRD GEGRICLEYL
SLYPPGIPLL FSGEKLTAEK IQGIEALEKE GIELQYSRHR QGESGRLIFQ KL
//
