ID C3JCC0_POREA Unreviewed; 603 AA.
AC C3JCC0;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN Name=topB {ECO:0000313|EMBL:EEN82167.1};
GN ORFNames=POREN0001_2011 {ECO:0000313|EMBL:EEN82167.1};
OS Porphyromonas endodontalis (strain ATCC 35406 / BCRC 14492 / JCM 8526 /
OS NCTC 13058 / HG 370).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=553175 {ECO:0000313|EMBL:EEN82167.1, ECO:0000313|Proteomes:UP000004295};
RN [1] {ECO:0000313|EMBL:EEN82167.1, ECO:0000313|Proteomes:UP000004295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35406 / BCRC 14492 / JCM 8526 / NCTC 13058 / HG 370
RC {ECO:0000313|Proteomes:UP000004295};
RA Sebastian Y., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEN82167.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACNN01000031; EEN82167.1; -; Genomic_DNA.
DR RefSeq; WP_004334692.1; NZ_ACNN01000031.1.
DR AlphaFoldDB; C3JCC0; -.
DR STRING; 553175.POREN0001_2011; -.
DR GeneID; 84818176; -.
DR eggNOG; COG0550; Bacteria.
DR Proteomes; UP000004295; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EEN82167.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004295};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..138
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 431..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 68184 MW; 708B81E739072887 CRC64;
MIVCIAEKPS VAREIARILG ANHPQNGFIE GNGYCVTWTL GHLCTLKEPN DYLPLWKRWS
LGDLPLIPQR FGIKLIDNED YKRQFEVIRQ LVEKADEVIN CGDAGQEGEL IQQWVLTKAL
CKCPIHRLWV SSLTDEAIRE GFTQLRTNEE MKSLYEAGLA RAIGDWLLGI NATRLYTMRF
PQPGRVLSVG RVQTPTLALI VERGRQIEHF VPTTSFELQT TYKETLFRQT AESFSTKEEV
EALIESIRSA PLTIKKVTKQ QGKELPPRLF DLTSLQVEAN KRFGMTAETT LQTIQSLYEK
KLTTYPRVDT TYLSEDIYPK VPAILKGLRP YEHLVTPILS SGKPPKKSKK VFDNKKVTDH
HAIIPTGVPL PSGLTLNENR IYDLIALRFI AAFYPDAKTA TTTVLAEVEG IELKATGKEI
LDPGWRVVLS SQKGKEDATN QGNKEEEGEP QEGKESLLPA FVEGETGPHE PSIRERTTEP
PKYYTEATLL RAMETAGKQV EDETLREALK QNGIGRPSTR ASIIETLFKR NYIRREKSSL
RATETGIQLI DTIQDPLLKS AELTGLWEYK LRQIESGEYS ASDFLTELKQ QVSDLVQSVR
RYH
//
