ID C3K7V1_PSEFS Unreviewed; 273 AA.
AC C3K7V1;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:CAI2797757.1, ECO:0000313|EMBL:CAY49770.1};
GN OrderedLocusNames=PFLU_3551 {ECO:0000313|EMBL:CAY49770.1};
OS Pseudomonas fluorescens (strain SBW25).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=216595 {ECO:0000313|EMBL:CAY49770.1};
RN [1] {ECO:0000313|EMBL:CAY49770.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SBW25 {ECO:0000313|EMBL:CAY49770.1};
RX PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT "Genomic and genetic analyses of diversity and plant interactions of
RT Pseudomonas fluorescens.";
RL Genome Biol. 10:R51.1-R51.16(2009).
RN [2] {ECO:0000313|EMBL:CAI2797757.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SBW25 {ECO:0000313|EMBL:CAI2797757.1};
RA Fortmann-Grote C.;
RL Submitted (OCT-2023) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OV986001; CAI2797757.1; -; Genomic_DNA.
DR EMBL; AM181176; CAY49770.1; -; Genomic_DNA.
DR RefSeq; WP_012724699.1; NC_012660.1.
DR AlphaFoldDB; C3K7V1; -.
DR STRING; 294.SRM1_03666; -.
DR PATRIC; fig|216595.4.peg.3699; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_2_3_6; -.
DR OrthoDB; 9772407at2; -.
DR Proteomes; UP001152918; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19138; AKR_YeaE; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
FT DOMAIN 14..259
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 52
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 77
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 273 AA; 30224 MW; 05EC14176C9138B8 CRC64;
MRTIDLAGVP VPVIGQGTWR MGENPDQQRA EVAALQLGID EGMTLIDTAE MYGEGGAETV
VGEAIRGRRD QVFLVSKVYP HNASHKGVPH ACEASLQRLG TDYIDLYLLH WRGQYPLEET
VEAFERLREA GKIGRWGVSN FDVADLQELA SPACATNQVL YNIEERGIEF DLLPWWQQHH
LPLMAYCPIA QGGELLASPT LKQIAHRHEV TPAQVSLAWV LRQDGVIAIP KAVTPEHVRL
NAAAAKLVLD EHDLDAIDRV FGAPKRKHPL AMV
//
