ID C3L4K7_AMOA5 Unreviewed; 4520 AA.
AC C3L4K7;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ACP20925.1};
GN OrderedLocusNames=Aasi_1610 {ECO:0000313|EMBL:ACP20925.1};
OS Amoebophilus asiaticus (strain 5a2).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Amoebophilaceae;
OC Candidatus Amoebophilus.
OX NCBI_TaxID=452471 {ECO:0000313|EMBL:ACP20925.1, ECO:0000313|Proteomes:UP000001227};
RN [1] {ECO:0000313|EMBL:ACP20925.1, ECO:0000313|Proteomes:UP000001227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5a2 {ECO:0000313|EMBL:ACP20925.1,
RC ECO:0000313|Proteomes:UP000001227};
RX PubMed=20023027; DOI=10.1128/JB.01379-09;
RA Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M.,
RA Rattei T., Horn M.;
RT "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus'
RT reveals common mechanisms for host cell interaction among amoeba-associated
RT bacteria.";
RL J. Bacteriol. 192:1045-1057(2010).
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DR EMBL; CP001102; ACP20925.1; -; Genomic_DNA.
DR SMR; C3L4K7; -.
DR STRING; 452471.Aasi_1610; -.
DR KEGG; aas:Aasi_1610; -.
DR eggNOG; COG0653; Bacteria.
DR eggNOG; COG0666; Bacteria.
DR HOGENOM; CLU_223632_0_0_10; -.
DR Proteomes; UP000001227; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 14.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.90.1440.10; SecA, preprotein cross-linking domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000185; SecA.
DR InterPro; IPR011115; SecA_DEAD.
DR InterPro; IPR014018; SecA_motor_DEAD.
DR InterPro; IPR036670; SecA_X-link_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 18.
DR Pfam; PF07517; SecA_DEAD; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR00906; SECA.
DR SMART; SM00248; ANK; 53.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00957; SecA_DEAD; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF81767; Pre-protein crosslinking domain of SecA; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 39.
DR PROSITE; PS50088; ANK_REPEAT; 43.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51196; SECA_MOTOR_DEAD; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001227};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT REPEAT 436..468
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 469..501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 502..534
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 603..635
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 649..681
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 716..748
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 749..775
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 787..819
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 820..852
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 853..887
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 923..955
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 956..988
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1022..1054
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1089..1121
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1130..1162
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1197..1229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1230..1251
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1265..1297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1298..1330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1331..1363
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1364..1396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1397..1429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1430..1462
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1463..1495
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1496..1528
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1529..1561
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1562..1594
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1595..1627
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1628..1660
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1661..1693
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1694..1726
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1727..1759
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1760..1792
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1793..1825
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1859..1891
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1892..1912
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1939..1971
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1996..2028
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2029..2061
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2062..2094
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2095..2127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2128..2160
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 2605..3276
FT /note="SecA family profile"
FT /evidence="ECO:0000259|PROSITE:PS51196"
FT DOMAIN 2696..2863
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 3134..3286
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REPEAT 3488..3521
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 115..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3939..3962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4072..4108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3939..3960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4520 AA; 503615 MW; 8321A7E7D1E5AF2B CRC64;
MLQSCSNPPI PPVLPSTTVQ DTDKKQISIL AKQGKYQTRQ LPVEFEAPIE EQLGDNTPLQ
VDVSLEDNVS MHAKMPFTEQ TKETVTGTDI VAPSSILPAS TTPSSKLNNQ LAVTAGKDEK
HHTSSTQSAK KHKQSKSRLK ALNLDEHIAK QQKRYQQTDK QGTENLSSQL LNKAGADTAG
TTPSSTTIAA EKAMEQVGQE DVIGQLQEKC FITKDGYQVT LRRVDDKWFA NVQPSWTRGA
RGLVYVPVYI EPGMRLAALL KFDEFWQKRR IHVMFAKEGD RKRAPIGVYV GVKGLLGAGK
TPLHEAFELR NIMALMDERC YGFLNSSGCG TLYPLSKYRH YLNEQDEMGI TPLHRAVCLE
FRWQFQSHKN LINEMVSLGA DINATDHKKQ TPLHWAVNNM QGDGEIIKYG RIVIDYPTII
RKLVDLDADI NAKDRRGYAP LHYAVEKNNQ YAISLLIELG ANKDIQDNNG NTPLHLAVEL
GNMEMAEHLI SLGADKDKRN NRTHLPLHMA ITCNQTELAK KLIDLGASKI TEDKYGNEAL
HLAIEQGNSE LVSYLIQKGA GLYWKNNLGL SPVDLASEKG RMDYVRQMFA TRRSEINSIS
WKDGVSHLHR AVQRKDLSLI KTLIDLGANK NLQEEFTRKA SDNTNVKILH RTPLHFAVEQ
EDISIIKCLI AAGADKNIPD STGKTPLQYV LQKAGRPIFS QLLNALGINI NEKDSNGYTL
LHRAVVEADV KLAEQLMAVG AQIDIKDKHG NTPLHLAIQQ KNLSLIKKML AAEASKSTKC
INVKNNDQQT PLHLAVTQGD TAIIAALLLG KADKVAKDKD GNTPLHVAVL TGSTAIIEQL
ISSNVDKDIK NNRGETPLHI ALQQHSSKDK LIELLKALKV NLQSKDSNGY TLLHTAILEE
DERLVSLLLN STLAVDKNAK NDFGKSPLHI AAEKGNLRLV NLLVALKVDI DIQDNQGETP
LHKAIQLGNA EIINQLINAG ANKDSCNNYG HTPLHLSVVY NQLQAAIQLR AKGALLCSMD
QEGNTPLHLA IYRQHPEFIK YLSQVGADLH LKNKLGFTPI DFASQNGYLT YVRQMILASH
TGINNIGVDG LSHLHRAVQH RDLQLVKLLL ILGADKDIKE KEASRGNTSL GRTPIHIAVE
QEDIEMIGHL VDVGADKDIT DSSGQTILQY ALQKINRPNF QKLLSALGIN INEKNRNQQT
LLHQSILEGN HELAKQLIAA GADIQAKNKQ EYTPLHLAAI GGHLELVALL IAKDKAKNPN
PKDKDGNTPL HLAVMQGKME IIRQLIRLGA DINEKNNDGD TALHLAVKKN DEKMVDLLIG
LKADRQVKDK QGFTLLHVAV KRNKPKMVDH LIALGLATNA QDHYGQTPLH IAVKENNLDM
VGQLVALRAD RQAKDINGDS CLYIAVKDNH LDMVGRLIKL NFDKNAIDHN GSTLLHIAVK
DNNFEMVGQL IKAGIAINQK DHNGHTPLHI AVQKGNQKIF DRLLKANADR KIKNREGLTL
LHIAVKSNKH KMVHRLITLG LVKNAQDNQG NTPLHLAVQE GNADMVDQLV ALRADRQAKN
KQGFTGLHIA VQANNLRMVR QLIALSFDKD AKDIEGNTPL HIAVKQDNIQ IVNQLVELGV
NVDVQNCASR SPLQLAIQAG NIKIVKRLLD LGVNKNIENQ AGDTLLHIAV KESDVKMVEF
LIEAGMDRAV KSKDGRTLLH VAVKENKPAM VDYLITLGID KNAKDHGGNT CLHTAVQEGN
ADMVYQLVAQ RANRKEKNNQ GSSCLHLAVQ VNNFSMLAQL VALNFDKHAK DNQGNTPLHI
AVEEGKEEIA KHLVQAGASL HIINKLGLTP IDLAATSKHI SYIDLVFSAT KSINTLGKDG
LTHLHRAVQR KDVKLIEQLI KCQADVTATD KVGKTPLHYA ASEGHTKLVK ILSAALKPKA
SLSSLFKKNS SLIDIVDNQG QTPLHLAIAG GHIGTVKLLL QQKASLYVKD KQGITPLQKA
LDAKQTALIK LVVNIPDCSP LHWAVEYNNI GLIKQLLVAG IDINTMDMHG KTALYMAFER
GNLELTKQLV ALGAAANATD SVGRTLLHHT IINGHLEVAK ALLAAGAKIN VPDNQGFTEL
HLAAQYNQPE IARYLITRGA VVDLRNNQQR TALHWAAYHG HAEVAIVLIQ AGADLQAFDQ
QGYTPLYYPL QQGKLGLVEL IAAASEHKIQ VSRCAYRARR RVTLPTVEQQ ESTDITERPK
KKKSPINQFI RRCLMDLPIE QRAEFEKTIV PLLKKHLVGT PHVLQKNVIQ YLENQGCFYP
SIFQEYKVED WVKESLILDI TKEALSKEDE VEFAKFIERL NAATQSYKQG ELEKLLGMLR
EKQLVYQLDL AAIADVLTYL IPFGATQALA LLEVPDMAWL SSLRLAWLGK QVKTLQHFTP
SQRRQISYAG TIFPCKPELL ERFIVGLQQE KDFSKVEDFF TFITKNPVSE TTLLMAFYQK
PKEVEASAIK AWKHYIACEL LKNTLAHRYA SHPTHRIEKQ LATLLDNHWL YEELHATLFE
LMYKNYTDVA TEAQCLSDIL DLLIEYGVDS QHCRSALQII QTRPCHEWEK VFHPRAIAAT
FGRSHERSAT EIIDFIVGNS PRTPFVNDKS ALESSYQAVL AAYQRTATLA PENKQIITNW
DKAAVIRWAE RVKGCAAICN MSADIQHEAL AVIKRAVKLT HGHEPRATQL LALLAFLNHV
PGKGRLAQIN TGEGKSLIVA MLAAMHALKG KKVDVVTTST ELSIPEVAKQ TRFFEVLGLS
VGENSNDNQK KDVYTRDIVY GTAGNFQGDI LKTEFSGKDI RGSRGFSVVI VDEVDSMLFD
SRHASIRLSG QTPAMHHLEL LLASVYSQVS RILRHLIEKD GITYYIHEDF EVVGDQITTF
SGNPLHMEPV SDKEQWITMR TQHHIENLLR PLTGDELQEW KEYKALNEKI VRKGFKAASE
EDEKKRKKYE ELCKKLGEEL KNLPWEKKGR SPVIEIPNHL REFAHKQIPL WIRSAIQAIC
FFKKELHYDV VKERIVPIDY DNTGVLQNSM VWSDGLAQML QMKEGLRVEA ENISTNFISI
PEFFKRYGSS IYGLTGTLGN VPTHQFLTEV YGVDKVIMPP YKYIPVAANI HSKYSCKELP
SIIVPNAQAW QEAIIRTTLS KARNHRAVLI ICKYIDQVNK LAKQLSTYYD ETKIFTYTGQ
ERFDKKSIEA GEIIIATNIA GRGTDITTTD AVERNGGLHV CITFLPDTYR VELQNAGRTA
RQGKQGTAQL VIQDSNNSSI EDLRSARDDK EGTAITRAKD DVHDMLLRDR LFNRFCALES
ELLPNVEYCT KEAQLKKLWA YFQTRRDKLF APGGKLDCTY EYEILKEASS RLYDRIKQQT
ATAFELRAIK HDLDTTKREL YKKHDKAALV KKLEKELVEQ TCSLAKGNFS VDVIERFRNG
YTTLPNGEEL ATKHDWGKHE RTGVEETWGL WLQHALKDKP EDDVWQEFST FENTIRERAK
GNALIRNPYY YVLKGNDFLF QGYTGKAVKA YNRAIELDPL HSVNAHYKRA WALLKPKKNK
DNILSAKRSL KHAKVLISTH HKPNLVSFNA MVAQTGAKPQ LLAHIQHQVD ILIKQESYID
AALREIKKAK KENWDIKLTE VKTLEQVFDD AEPGENRGPA ISKANINGLS HMFVITAKQP
FPWKSIIALA IIGLAQVAAG VLVCACTGKI DTGLGFINEG ISDLLATFKA VKSGTFSWAQ
WGIQKAISLA VAIISCGWQG IKDTFKTVKE TAQKIGTVGR GIAQNGVKAA INKAAVELGK
GIVKEVVNSA VNHISEKLII ENIEGYIEKK IVKKLEKRLL ANELMSKALS LDVKNKNNYW
QQILIQEGMG LLHKPDSKFE QFLKGPGATL LKAGLAKMNQ LMAAEGGSGV KVFQDALKVR
AMADALFEIL NMTDKFFSDF ADKIELKYKA DIEKAAQEQA EKENAKKEGK GKEKEEAHTS
TTEQVIAPPE VEQGEIKTAR VGSGTTYNSQ VESKGEAVRE YYYGAVSSKG SLSKVFAGSL
KAKITNKIQG EFIQPATSSL VSMGVDKLSE GLTERANAGL VAFRAEHHTH DIGDKLATTK
KDEKQEQAGE STGKKLDAHS EQKAKAVAEG KRGDITDVAL LAKTVKRPII IYKNGKIYNI
IGKDLPGEPI SLSHSSEGVG HWEPIDKSIQ VNVSGEYNCL YDAVAAQMSS AEREKLGVQN
GQDFRQHIVK EIQTNATITQ QFMAQAAELS YLKPAAMMEG GLEYNFDMLA NGGRGAFVKI
SDKGGNDTDY YNAGHYEVEL GPDQQPLKDE DGNFKRKFVS DKTLDFARKA GSANIFRIAQ
SKYSTLSINH VPTHDGANDF SFVGLEPKGP STHLRDLNRR IPATVYNTRY HGWGRHKGKF
NIFNTHPLKE MRVDADRTIL GHLGINYHDT EGCLLIGSYY KTDQPIFEKE RDEKTGEVKR
KPDGQIKWIP TIDEDTGKQV QDIEIEPSRE NLNALHGGFK KSGKNKAGSY NAELRYTELY
KEAEEARKKV EEQEKKYGNG
//
