ID C3L4M4_AMOA5 Unreviewed; 2279 AA.
AC C3L4M4;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Aasi_1629 {ECO:0000313|EMBL:ACP20942.1};
OS Amoebophilus asiaticus (strain 5a2).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Amoebophilaceae;
OC Candidatus Amoebophilus.
OX NCBI_TaxID=452471 {ECO:0000313|EMBL:ACP20942.1, ECO:0000313|Proteomes:UP000001227};
RN [1] {ECO:0000313|EMBL:ACP20942.1, ECO:0000313|Proteomes:UP000001227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5a2 {ECO:0000313|EMBL:ACP20942.1,
RC ECO:0000313|Proteomes:UP000001227};
RX PubMed=20023027; DOI=10.1128/JB.01379-09;
RA Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M.,
RA Rattei T., Horn M.;
RT "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus'
RT reveals common mechanisms for host cell interaction among amoeba-associated
RT bacteria.";
RL J. Bacteriol. 192:1045-1057(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001102; ACP20942.1; -; Genomic_DNA.
DR STRING; 452471.Aasi_1629; -.
DR KEGG; aas:Aasi_1629; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR HOGENOM; CLU_000445_34_2_10; -.
DR Proteomes; UP000001227; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009882; F:blue light photoreceptor activity; IEA:UniProt.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000001227};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 234..493
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1719..1791
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1794..1847
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1876..2113
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2139..2270
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 1838..1866
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 2200
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2279 AA; 257124 MW; 76C87E6B02FE8562 CRC64;
MQSCVNLTNS PIPIKKGQTD HTQEIIPQIA IRSIVDIEFT TKGGHLITFY EKTGRLQAEV
IEQNEGLSKV HMLPVYIEEG MDIAQVAQLN EAAQKRFIHI NLPKRKDSGS IWIGHAGLKG
GSNTGKNKGK EKLKDDQYQA LEEKKLIAQA GQLISSKQEI NHLKAKGEGN SPSEFNKTYD
LSVPVEKELH ATSSIKEEQK QLIHANLAKS EQTGYLQVGG MELKRENHLV LPGYKLLHCL
HEGTSSNIYR AVRLSDECPV VIKVSTQKVL TEKKAQRFRR EFELGQQVHS PYVVRYLELK
QDAAYGMAIV MEDDQAVELN AILPPTGFSN QEFLEIAIQI VEGLQAIHAA NIIHSDLKLN
NILIQPTTNL IKIIDFNRSS TLRQERPPTM PMMVGTLTYI SPEQTGRVNR SVDYRTDFYS
LGVTFYRLLC GEPPFTAKDA LGLIHQHLAR QPIPAHQHKP TVALSLSRMV MKLLEKEAEN
RYQSCEGILH DLIVCLSAFK ETGAIPEFEL GQQDFSSKLT LSQNLYGREK EIKTLEKAFE
RVSEGRCEAL MVAGEPGVGK TMLIQEIQKP IALQHGYFIT GKFDQLNKNV AYSAFAQAFN
SLVQQWLTED QTSIMQWKIR LMESLGTQAS LLIKVIPSLA LLIDEQPETA IADMSQAKNV
LNWIFQEFIK FCTTPSHPLV IFLDDLQWAD QASLELMTYL MTQPSIKHLL WIGAYRDTEV
TPSHPALQSI TALQEASITV QTLTLAPLQL KNLCQWITDS LHKSIMDAQP LVELIFQKTA
GNPFFVKLFL QSLYDEQLLT FAPQSHWQWD LDKIRQHPAT ENVITLMTYQ IQQLPVSTQQ
ALSIASCIGH RLVLSTLQTA MACSHQELEK SLQPALNSGI LIQTDHEIYF AHDRVQEAAY
HLLPETIKTR THLMIGRRLL VSPTSEEKLL SDIVAQFNRC CSLVTDSQER LHIARLNLKS
GQKAKQSTAY GVALDYLHTI PKWIDTEILW QSDYPLAFTF HKELAEVEYL GGYMDTSQAI
IADMQPRLQS NLDKVDIYHL LIIQKTLQGH YQEAIALGHK TLQLLGIWLP LDNLTEFIQK
ATDDIKQKLH NIPLSSLLNA PLVVEPEKKA LLKILESLVA ACYFAGSELL TAATLMSIDL
ALTYGHAPES CLGYTVYGSL LCNRFEEHAL GYEFGQLSIQ LAKKLQAPAQ HCKSLLIMLA
LISPWSKSIQ QLPALLTDGY KVGLACGELE YAGHCVSMKA QLLFYQGMSL AKVQQEILPL
LQFTYNTKNQ VAINTIQTVQ RLVVNLIGNT LDEWNFDADA ITEARFKKSC QQASSFYSLC
LYQILKAQTF YLYGHFKQAF GQLALVKQHL VLILSQYATA LFNWYDSLVR LALYPTSSIA
DQQIYLQQVI KNQQQMQKWQ ASCPANFAHK YALVEAEIFK LQENYQQAEA YYDQAIELAD
RHGFIQEKAL AAELAAKYWL TRGKTLSAQG YLNTAFNGYK QWGAKRKLMQ FKTQYEYLLK
DLVPPSLSYL TVNQETTLSS NTLRYLDLSS ILKASQTISS EIELPKLLRN MMQIIIENAG
AQQGAVLFVE AGDTVVVQAE YASDNTITTL QKIPLADWEH GAHTVIQYVK RLHQSVVLDN
ATIHEQFKID PYINRTQAKS ILCIPLLKQT ELRAILYLEN NLMTHAFTPE HMQTVLILTA
QIAISLENAR YVAEQLALTQ QLAEQSTRRK IAEESLHVVT HDLKLALEAS QAGTWSWWID
SNKVVWDATM YALFGLTPDT FRGTFEEVRE RVHPEDKEQF EKNIDNCVKQ STPHSIDYRV
IWPDGSQHMI TAHGQVYRDT TSGSPIKMTG VCLDITERKK LEQDRLEALQ QAKEKEQQRA
DEAERYFKQQ EEFINTVCHE IRNPMNGISN TVVFLEEKIT SLKKLKESLP GSFQPELKEL
LPTLEEDIQT IQHCVNHQLV VINGVLNLSR LEAGKEKLLL KPFKPKTIIE ESILLFTSQL
KTKQLNLIID LPKQAIAIQG DPERFKMILI NLISNAIKFT EKGHIKISFQ TQAVDSTHVE
LVIRVEDTGI GMTPEEQSCL FQRFSRPLSS QYEGSGLGLA ISKKLLDLMG GTIQVDSVKG
QGSTFTIHLT CEMVDIGEKL IYQKPPAPLP ILPPIAVKHI LIVEDNIVNQ KILRRQLEAA
GYTCMVADNG QKAIEAIGAI EEVETLEQWN LAAFDLILMD LEMPVMGGIE ATGWIRKKEQ
QLGVPSIPII GLSAYAEEIY GETAKKAGMD AYNTKPYRKE ELLKTIQSLL SRPLEPASE
//
