ID C3XQ16_BRAFL Unreviewed; 1609 AA.
AC C3XQ16;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Malignant fibrous histiocytoma-amplified sequence 1 homolog {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_67388 {ECO:0000313|EMBL:EEN70037.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|EMBL:EEN70037.1};
RN [1] {ECO:0000313|EMBL:EEN70037.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN70037.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN70037.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; GG666451; EEN70037.1; -; Genomic_DNA.
DR RefSeq; XP_002614028.1; XM_002613982.1.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG3573; Eukaryota.
DR InParanoid; C3XQ16; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR PANTHER; PTHR45752:SF149; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 39; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00656; Peptidase_C14; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00369; LRR_TYP; 19.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS51424; ROC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 768..981
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 1343..1465
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 1515..1604
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 1493..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1609 AA; 183416 MW; 3FD51CD42AE6E40B CRC64;
MGIDLSTYRA RIGCFSNPGH DSLHCWAEAS CLLVWMVISQ LMLKLAGDVE ENPGPQERYL
GKTMGTQPMR DEMKREEWKI LGKAQPLWTL DLSNQNHKDL PDEVFELEEL EALKLTYNES
ISLSNKLVKL TNLKVLCLEN CNLDKLPPVV LKLSHLQVLD ISKNKAISLP KMILKKLKKL
KVLKLRDCDL VTIGRQIFQQ ESQLEELDLS GNMQIDLPDE LRTLKNIRVL RLNRAGMTTV
PPAVLELSQL EKLDLSGNKQ IKLSDQLLGL TNLKVLRLSR TEMASVPEVV WKLTHLEELH
LLSNPLQTLS VKVGQLSRIK RLDLSNCHLR TLPPEVGTLT QLERLKVANN RALQTLPGEL
WQVTNIKRLD LSNCQLHTLP PEVGTLTQLE WLDLSFNTLQ TLPRELGHVT NIKRLDLSHC
QLHTLPPQVG KLTHLKWLKV KNNPLQTLPG ELGQVASIKH LDLSNCWLHT LPPEVGTLTQ
LERLKVANNP LQTLPGELWK VTNIKRLDLS SCWLDTLPPE VGTLTQLEWL SLQGNPLQML
PKQIGQLTAI KHLNLSFCQL HTLPPEMGTL KQLEWLSLQG NPLQMLPKQV ENLTHIKWMN
LSHCRLQMLP PEFGKLTQLE RLYLSCNGEL QTLPTRQLTN IKHLDLSNCS LQTLPPEVGE
LKHVEYLRLS SNPLQKLPPE VRHLTNIKHL DMSNCRLNEL PIEVGTMTQL RQLDLRYNQL
QMLPVEITQH INLYHLDVRG NPLIRPPAEV CSQGMVAVRQ YFEELESGEA VSTHLKVVVL
GKELAGKTSL IQTLLSGDSS LTQQEDRTHG VEITQWKPDD NITFEVYDFG GHDAYHLTHQ
FFLTQDSLHL LTVDLQTYCC TEQDYKNAVG FWLDTLNARV PGAMVTIVCS KSEGSVDIEK
KTHDIEVKFK EQQDTWKRNL ERQLKIIERA ENQEDLKQQF EDIQQLMTRP LQFKGLCCVS
SAGPTGLETL TAHVLELAKN TQLFQTHKGI LPQTWVDFEQ RLRNLRDNEA KWLMPADYQQ
QAQLAGLPTD KLEPVLSYLQ QVGTILRYTD IPELRDFVFH DPPALIEIFK GLFHHNTSDL
FSTLDIYFTP LDLDKFKSDL DDRGLILKKV MKHLLPPDTP SNIVTSLMQH YDLCFEIDEC
KTKASDEETR QYMIPWYLHK TMQEKWQHNW PQHVPEEQLQ LMCNIKGFCP RGLFPRFSVG
IHSLIKDRVD WKDSVMAYRQ DFPVLALCSK PGTDDTYITI ATRGRLAQAD EMWGVVYPLL
EVLVQLLQKW PGVLYSLHVT CAHCIKARLD NPHQYNLRDQ TADDDRIVRC PKADFRATVS
TDLVYRPLQQ NKVFQRYKMK TDPRGLALII SNINFMDPET DRQGGNKDLE NIWKICDKLK
LKAENKDDLT GQEIADTLQE VSERDHSCYD CFVLFLLSHG DEKGVLGTDE DRMISVDSIT
SSLQLCKSLV GKPKLFFIQA CRGDNFDEGV EYMTTDDIKS PSRVGAEALS ESIMATDSAS
HQSTTPTASD SGNAKRKTIP TASDRLVMNA TVQGQVAWRD KNTGSPFIQA LADVITEHAD
TVTLQDMATL VNEKVADYEA DADDDYKQQS EVSHSLRKKL YFFPETAVD
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