ID C3XQ80_BRAFL Unreviewed; 1642 AA.
AC C3XQ80;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEN70101.1};
GN ORFNames=BRAFLDRAFT_67322 {ECO:0000313|EMBL:EEN70101.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|EMBL:EEN70101.1};
RN [1] {ECO:0000313|EMBL:EEN70101.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN70101.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN70101.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; GG666451; EEN70101.1; -; Genomic_DNA.
DR RefSeq; XP_002614092.1; XM_002614046.1.
DR eggNOG; KOG4194; Eukaryota.
DR eggNOG; KOG4308; Eukaryota.
DR eggNOG; KOG4348; Eukaryota.
DR InParanoid; C3XQ80; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46312; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46312:SF1; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52047; RNI-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1463..1488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..95
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 389..515
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1236..1358
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1363..1449
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1557..1616
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1522..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1642 AA; 182805 MW; F7AB6CDD2B96B96F CRC64;
MAEGQGSSDT GVRRFFYFTK EKVSSDWKDL AFHLEFEQAD IDNIAGRNPD DKSRCMDLLE
EWLKCKGERA TMEVLMEALS KASLQSTVDG LKKEFPEIPP RLPIVVEILA QVKPTVKTPK
QLLNYAKARG FLDITAITDE TLGLLEQIKP EIKTIKDLLD TTKAIRKLQE TRGVRVTDVK
MGSLVFYLQC TDLEGLGELW FMYKRGELDN LLHGSLVSEE TLQHLCAETI SVKAAINLED
FRKALLYLLN RSVFQERCAP RLPREFPIYQ PTHATSDVLR VTLNHLDQED LPDSWGERHA
REMPLQEDGK DHLSSKFDKM QIGDAFLGSI RKHYELRLTK FKPLIWNDNF ALTIGDIFTE
LDFSSAKVKK LDDLFNSSTN GQSRSAARRC ILIEAEPGGG KTTFMTKEAL DAVSQKTELG
KRHDIVLLIR LREVKEGETI EEIVWDQCVD ETTEGVDVQS IKTILQRNQS RVLFLLDGYD
ELQPEARADR QAIPKLLSGK VYPNSTIVIT SRPAAGVQQH TQPDCCASII GFTFRHHCKR
EGVDMPTDGI PSDLADALLQ LGKLALEALL RKETQLDIAE VERQNVNWEL MLKLGVVFSE
ASASKLHPRK QLTFAHKMMQ EFLAGRYVAS VVLNQDIRDL LKITSMSNVL EHSNLLQFAC
GSSDSRAAQA VMEGLANLSS KEYEGLQVEN ITKLDWPWIP KPEVRNDYNA FARLCLGILN
ENMDPGVLQA VRRALPFMVS HNAINSREHA ALKYYIQNIP PSAQSLQQMA LEMGGPSQFV
TAQVLQFLEQ TFPSPTPGLL LDLSMSGIFL GAPELTERLV SVLKHVPGLR RLDLSETYQF
APSLQPIIDA FSHMPMLEEL DLSWMELGDA EIEVVQEGLK RLPHLAVLHF KANIYEQEIT
ITAKGMSILA PSMRKLTGLR ELDISCNAIG DKGMEHLVDV LPIFTAMQIL ILAQVGMSIT
GMRKLVRALR YLTGLLKLDI SENHIGDIGL ECLADILPGL IAIKVLKLSE TGIGDKGMSA
LVKALPYLME LQVLDVSNNQ IGDSEIVALV QTLCRSSTLD IEQTPLGDKR QALVGSHVQE
LDFSENTGVT AAGLERVSHT ITLPALTTLK MSTYPETLTH LPDSSAMAVV EALPRLPALE
RLHLGYITMD PVGFKAVVQA AEEHPTLREL WYTKEGVPEG ADTSAHCLTW STTLERCADI
VDTSKIFFTS LPSRRHDWPI CRLQMGSCHG ADDARPRLTS AEVTVSLAQS DLRLDVPTKV
STIVGDPVTI PATFRTTRRI MSILWSKSGK ENARQPVMSS YPIADTTEAH AGFDTKFSGG
TLQNPNLVIR HVTRGDAGRY RCIVDHVIKS ASAALNLQVL YAASVISVSD SRTAVISESV
TLQCTADGNP PPNVTWTRNG LPVRSSTRSL SRDVRLSSVV LPNVQLNASG TYVCTASNSV
GKSDVKSLQL VVEEYSMDEK SSMIAILVGA LAGGLWLIIC LVLAVYFFRR RREREEKKKF
SFYYNMGRRG QETINKKLQE DTLDSGRHPN PQVPAKPMLP TAPNAGIETL RRTKKQRERR
YAKAMYPYYP QDDNELCLEI DDVIEVLEGE DGGWCLGYLR GRIGLFPSNY VKFLTAKEAS
AAKLKDLHEG KDAVKLPTKG SI
//
