ID C3XTB1_BRAFL Unreviewed; 407 AA.
AC C3XTB1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Alanyl-tRNA editing protein Aarsd1-like {ECO:0000313|RefSeq:XP_035658313.1};
GN Name=LOC118403646 {ECO:0000313|RefSeq:XP_035658313.1};
GN ORFNames=BRAFLDRAFT_127497 {ECO:0000313|EMBL:EEN68700.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN68700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN68700.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN68700.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000313|RefSeq:XP_035658313.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035658313.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035658313.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Alax-L subfamily. {ECO:0000256|ARBA:ARBA00008429}.
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DR EMBL; GG666462; EEN68700.1; -; Genomic_DNA.
DR RefSeq; XP_002612691.1; XM_002612645.1.
DR RefSeq; XP_035658313.1; XM_035802420.1.
DR STRING; 7739.C3XTB1; -.
DR KEGG; bfo:118403646; -.
DR eggNOG; KOG2105; Eukaryota.
DR InParanoid; C3XTB1; -.
DR OMA; KYDTTSW; -.
DR OrthoDB; 5490212at2759; -.
DR Proteomes; UP000001554; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0002196; F:Ser-tRNA(Ala) hydrolase activity; IBA:GO_Central.
DR GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0006450; P:regulation of translational fidelity; IBA:GO_Central.
DR Gene3D; 2.40.30.130; -; 1.
DR InterPro; IPR018165; Ala-tRNA-synth_IIc_core.
DR InterPro; IPR018164; Ala-tRNA-synth_IIc_N.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR012947; tRNA_SAD.
DR PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR Pfam; PF01411; tRNA-synt_2c; 1.
DR Pfam; PF07973; tRNA_SAD; 1.
DR SMART; SM00863; tRNA_SAD; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT DOMAIN 1..248
FT /note="Alanyl-transfer RNA synthetases family profile"
FT /evidence="ECO:0000259|PROSITE:PS50860"
SQ SEQUENCE 407 AA; 45097 MW; E25FF022C6332689 CRC64;
MALQCQQNSY LTEFSSKVVS CNPGQLVISK KKKQPGYEVI LEDTILFPEG GGQPDDRGKI
NDVDVIRVTR KQNQAVHFVE TPLEVGSEVK MEVDWTRRFD HMQQHSGQHL ITAIAEAKFG
YKTTSWDLGS KVSSIEMDTP TITLEQLSEL EREVNECIRR QIPMTPRLLE PGSPELEQVR
SRGLPDDHIG PVRVVEIEGI DHNTCCGTHV SNLAHLQAIK LLSLEKGKKG KTNVMFVAGN
RVLDFVGRAY DREKGLTGIL KCPPEEHVEM ADKLQKSLRI SNKTCTGLLR DVAVLEAQRY
KSQPNRDPVF CLHRKEGDSE FMNIIANEVG NENALVLLSV GDEKGAGTFL LSGPADVVEA
VGPKVAEVLE GKGAAKRGRF QGKATKLANL KLAEEVLREH FKTQEAA
//
