ID C3XXM4_BRAFL Unreviewed; 625 AA.
AC C3XXM4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=PIN domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BRAFLDRAFT_117205 {ECO:0000313|EMBL:EEN67484.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN67484.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN67484.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN67484.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785}.
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DR EMBL; GG666471; EEN67484.1; -; Genomic_DNA.
DR RefSeq; XP_002611474.1; XM_002611428.1.
DR AlphaFoldDB; C3XXM4; -.
DR STRING; 7739.C3XXM4; -.
DR eggNOG; KOG2102; Eukaryota.
DR InParanoid; C3XXM4; -.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR033771; Rrp44_CSD1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 61..182
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 471..625
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT NON_TER 625
FT /evidence="ECO:0000313|EMBL:EEN67484.1"
SQ SEQUENCE 625 AA; 70771 MW; 858F2BE6519D4B5F CRC64;
MLKSKTFVKK TRKGGVLKVV REHYLRDDIW CGSAACGGCP QERPVLEAEP EIDSTLCGFP
HYLIPDTNVV LHQMDVLADS AIRNVIILQT VQQEVRHRSG TTYQRLRDQS NNPDKHFYVF
TNEHHRETYT EREQGESSND YNDRVIRVAT RWYNKHLQEN RKDGDTPKVK VVLLTNDGEN
REKAQKEGLL AYTVHQYVKA LKGNPELVDR LAQVDMGEST DSDIKNEATG RVLFPEHLPL
SQLQTGIKSG RYLQGSFMAS RENYLEANVL VHGDDSRSIF IQGHAHLNRA VNEDVVAIEM
LPEDQWKCPS SMVLQDKDGD EEVRVEKLVL SCSCQFILVN RAISKTRRVV GVIKRNWRPY
CGALQPSGIK EATRHLFMPA ERKIPKIRIE TRQAESLQGQ RIVVSIDGWP RGSRYPKGHF
VRKLGEVGDK DTENEVLLLE HDVPHQPFSQ AVLNCLPSTP WGITKEDLAC REDLRDIPIC
SVDPPGCTDI DDALHYVEKP NGNIEVGVHI ADVTHFIRPN TALDQEAANR GNTVYLCDKR
IDMVPELLSS NICSLRGKEE RFAFSCIWEM TKDADIVSTR FCKSVICSKA ALTYAEAQMM
IDDKNRNDPV TVGLRGLNAL AKILK
//
