ID C3XYS2_BRAFL Unreviewed; 462 AA.
AC C3XYS2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Nodal-like {ECO:0000313|RefSeq:XP_035670499.1};
GN Name=LOC118412021 {ECO:0000313|RefSeq:XP_035670499.1};
GN ORFNames=BRAFLDRAFT_271926 {ECO:0000313|EMBL:EEN66957.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN66957.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN66957.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN66957.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000313|RefSeq:XP_035670499.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035670499.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035670499.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666473; EEN66957.1; -; Genomic_DNA.
DR RefSeq; XP_002610947.1; XM_002610901.1.
DR RefSeq; XP_035670499.1; XM_035814606.1.
DR STRING; 7739.C3XYS2; -.
DR KEGG; bfo:118412021; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; C3XYS2; -.
DR OMA; CHQVGDR; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000001554; Chromosome 3.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..462
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040661373"
FT DOMAIN 343..462
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 256..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..278
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 52561 MW; 343F0BAAE08C2FED CRC64;
MPAPRPAMGT FLTASVAFFA VQLLQCECLS NEHTLAASGL LRASGGEGLT LGRYEHGDGV
VNVTMRGMAV AGRMTPEFML DFYQSLSSGT DLNVTREENQ ALPLPSDTVR SFALKDAKQK
GSKKFSYVFD TSNISPDTDI RLAELRMRGP HFSPPRRLSV RVFSHEEKKC KKKKEGATCT
VKHRIASFKH IQEDLTADGW RVVDLTKKLS RWVRQNVSAD TIEIQITSKP ERRRPRDLST
DASDWLMLMK NMSPVREERD TSFDESHSED EESDFYGTDE PDAESRQKRR VEIKLSEDVS
LVVFSQDQKA DLLRDSQKAK RAQHPVRHDH QAETRVARSN RRRQKKSKKG KTDSSKKEDT
PCKKVEFWVD FDHIGWGTWI IYPKRFNAFR CEGVCPTPVD QLYHPTNHAV MTSILNLHKP
GKAPMPCCIP TKLKALSMLY LEHGEVVLRH HEDMIVDECG CQ
//