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Database: UniProt
Entry: C3XYS2_BRAFL
LinkDB: C3XYS2_BRAFL
Original site: C3XYS2_BRAFL 
ID   C3XYS2_BRAFL            Unreviewed;       462 AA.
AC   C3XYS2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Nodal-like {ECO:0000313|RefSeq:XP_035670499.1};
GN   Name=LOC118412021 {ECO:0000313|RefSeq:XP_035670499.1};
GN   ORFNames=BRAFLDRAFT_271926 {ECO:0000313|EMBL:EEN66957.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN66957.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN66957.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN66957.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
RN   [2] {ECO:0000313|RefSeq:XP_035670499.1}
RP   IDENTIFICATION.
RC   STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035670499.1};
RC   TISSUE=Testes {ECO:0000313|RefSeq:XP_035670499.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; GG666473; EEN66957.1; -; Genomic_DNA.
DR   RefSeq; XP_002610947.1; XM_002610901.1.
DR   RefSeq; XP_035670499.1; XM_035814606.1.
DR   STRING; 7739.C3XYS2; -.
DR   KEGG; bfo:118412021; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   InParanoid; C3XYS2; -.
DR   OMA; CHQVGDR; -.
DR   OrthoDB; 5393576at2759; -.
DR   Proteomes; UP000001554; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13759; TGF_beta_NODAL; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..462
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040661373"
FT   DOMAIN          343..462
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          256..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..278
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  52561 MW;  343F0BAAE08C2FED CRC64;
     MPAPRPAMGT FLTASVAFFA VQLLQCECLS NEHTLAASGL LRASGGEGLT LGRYEHGDGV
     VNVTMRGMAV AGRMTPEFML DFYQSLSSGT DLNVTREENQ ALPLPSDTVR SFALKDAKQK
     GSKKFSYVFD TSNISPDTDI RLAELRMRGP HFSPPRRLSV RVFSHEEKKC KKKKEGATCT
     VKHRIASFKH IQEDLTADGW RVVDLTKKLS RWVRQNVSAD TIEIQITSKP ERRRPRDLST
     DASDWLMLMK NMSPVREERD TSFDESHSED EESDFYGTDE PDAESRQKRR VEIKLSEDVS
     LVVFSQDQKA DLLRDSQKAK RAQHPVRHDH QAETRVARSN RRRQKKSKKG KTDSSKKEDT
     PCKKVEFWVD FDHIGWGTWI IYPKRFNAFR CEGVCPTPVD QLYHPTNHAV MTSILNLHKP
     GKAPMPCCIP TKLKALSMLY LEHGEVVLRH HEDMIVDECG CQ
//
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