ID C3Y007_BRAFL Unreviewed; 903 AA.
AC C3Y007;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=BRAFLDRAFT_209377 {ECO:0000313|EMBL:EEN66373.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN66373.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN66373.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN66373.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; GG666477; EEN66373.1; -; Genomic_DNA.
DR RefSeq; XP_002610363.1; XM_002610317.1.
DR AlphaFoldDB; C3Y007; -.
DR STRING; 7739.C3Y007; -.
DR eggNOG; KOG1480; Eukaryota.
DR InParanoid; C3Y007; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 337..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 7..106
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..203
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 497..635
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 831..897
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 454..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 99969 MW; 0ABCAF57D08559C0 CRC64;
MGGGDLPTFV IHPTDAYIVK NRPVTLTCKA TPAIQIYFKC NNEWVRAKFH KHFDSTDPET
GVSYKQTSIE VTKAEVDQRL EETGENFFCL CVAWSSEGSS RSEEATVQIA YLRKDFILEP
ISQGVPNETP VQLQCRPPEG VPTPEVVWLK NDEEIQVDLD INFIITNEGN LIINQARLSD
TANYTCVAKN IVTKRRSVTA RVTVYVNGGW STWSTWSECN SQCGRGLMRR TRTCTNPAPL
NGGATCDGDP VQRAECTTLC PVDGGWSEWS KFSACGRDCN NWRRRECNDP PPQFGGRYCI
GDNMETRNCT GGLCRGKNRP AFSPFPFLIP ARSEDNLALY ISLVGAVTVF LLVCLFIIVV
WWRKNRHSGE SLEPASVMNC DFPPGNVKPA QRNSPALMSY VAQPDLTRST GNVRGFPVMP
TLAFSDDKIP MTMSPLHSNN SLKIKVRNAQ IMSNSLPDMQ PSTPEMSDVG TSTRRPSSIY
DAENLAKILP SYVDPAFAAC GTIGAEGGRL AIQESGVSLL IPSGAITDGH TEDIFIAVLR
EEKDRPKMNA KQTLLGPVVA VGPHGLHFRK PVIVTFGHAA GLRERNWELT LLSSESHPNR
SPSWQNLVLI GEETLNTTAY CQVDERDCHV MVEHLSSRYA LIGQSAPATQ AVKRLRLAVI
AAPLQPSGDY NFRVYCVADN SDELEGVVQS EAMLGGQMLD TPKILPFKDN GRDLCLSIEE
TLPGWKSRLG ANFQEIPFHH VWGSSQTGLH CSFMMERTDP QIQMVTARIQ VFQGSPEEER
QSLNITASVS REVRSLLLSS HAPQTPAEVF RLPPAVRASL RGCLDIPNVK GNDWRGLAKR
LQVDRYINYF ATKPSPTDHI LDLWEARNRD DRAIEELILV LKDMGRSDAC LLIESGVSTP
LVA
//