ID C3Y0L6_BRAFL Unreviewed; 3194 AA.
AC C3Y0L6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEN66289.1};
GN ORFNames=BRAFLDRAFT_126840 {ECO:0000313|EMBL:EEN66289.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN66289.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN66289.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN66289.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG666478; EEN66289.1; -; Genomic_DNA.
DR RefSeq; XP_002610279.1; XM_002610233.1.
DR eggNOG; KOG1214; Eukaryota.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG4291; Eukaryota.
DR InParanoid; C3Y0L6; -.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00255; nidG2; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 38.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12947; EGF_3; 13.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR SMART; SM00181; EGF; 42.
DR SMART; SM00179; EGF_CA; 35.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 9.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 33.
DR PROSITE; PS50026; EGF_3; 38.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3194
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002933341"
FT DOMAIN 296..525
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 526..567
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..606
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 616..659
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 853..894
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 895..934
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 942..980
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1036..1075
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1076..1115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1161..1202
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1205..1246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1249..1290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1293..1334
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1337..1378
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1381..1422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1425..1466
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1469..1510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1992..2036
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2040..2078
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2083..2121
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2122..2161
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2164..2203
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2207..2248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2249..2290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2291..2327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2330..2368
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2369..2407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2409..2449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2470..2508
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2509..2547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2551..2590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2591..2628
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2640..2682
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2687..2728
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2735..2774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2789..2830
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2831..2871
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 2933..2975
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2976..3018
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3019..3063
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 2418..2435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2651..2668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3194 AA; 344899 MW; 8D90A680AFFDC563 CRC64;
MSPLVLWSFL LGLLVPLTFG LTRTDFYPYG VEYGDSELRK GDEVSSDPIP LFSPVYFYGT
RYQSLFVSTN GIISFGKAVS EYITERFPLD VSVISVFSTD VDTEAAGQVF YRESTDQQLL
VQASTAVRKY FPDQSSDFMA NALFIVTWVD VGYYPDGDDK IWNLCTVFWS NMNTGGAWLF
QIGAFAGFQN IIPAQPKLES PIVDSDRSTS FNRNREPLVE VAPAPVDRTG QFNRDETPSN
QDPFQVTFYN LDGQGQSAGC DSCHQNARCS RQGSISCCRC QEGYYGNGIN CLPAGTPQRV
NGKVEGTVRL SGKDEVDLRD IDLHSYVVVN DGRAYTAMSR IEENVGYAMQ PLSTIGGIIG
WLFGLPQANA VNGYTLTGGV FKRSAVVTFR PGNQVFQVEQ DFQGVDEFGY LTMTTKLSGE
LPPIAAGDKV VVGEYQEIYQ KTAPGLIKSI ASRGYTVANR VYNYTWDQTI EYDEAGCNLP
AEGLVTDSLR VDVSRNFVFF DNKEEIVRYA MTTKVSPMAG PPVAPVLNPC QTGQHDCHSR
ARCVALEGQQ YTCECVGGYT GDGRNCQDID ECTSGTPPCA PNANCINEIG TFRCVCPPGY
EGDGFSSCTP LSPQPSQNPC YDGTNDCDSL ERARCIPLGA GRYRCECNPG FTGDGRTCVG
RSWVTEFKFE HPCVEGSHGC DEETSMCVKR AGLRYEYYPN PCNKTSCGRH AVCVGRYNPD
NDEASLICKC KPGFVEVAGK CRPKQSVVWK GVNTTKKNKN KTRRTKRDLM KIDSMSPASQ
LQNPCVGNRC DVNAVCIPNP VPSDCPCKQD YTCMCQPGYT GTGYNCRSNP CHSGESMCGI
NGVVRMTKSA SLPVNPCYTG DHMCDTNAYC VAGVANEYEC KCMPGYSGTG FRCDAASPCS
NHDCHPAADC VEINAFKFMC LCGPGYAGDG RTCVLSLDLA TSTDPCEQNR CDPNAQCIPY
QDRYSCRCNQ GFQGNGLQCT PELIQPYDAC AQNTCDPNAD CIAIGSAYTC KCQPGYIGDG
FGCYPDRGAL TGETRQSGVC GSSICDVNAI CVDRGEGIYT CECKTGYRGD GRTCSAANAC
EQSNRCHERA ECIPLGNSYT CRCQLGYTGD GLTCTSISRD PCNPNPCGAS NRCLAQGSTY
RCQCSNGFEL GPAGTSCLRQ AVDPCNPNPC DPRNGRCVPQ GSTYQCLCNP GFQLSSDRRT
CTRQAVNPCS PNPCDPTNGR CIPQGSTYQC TCNAGYQLGA DRRTCTRQAV NPCSPNPCDP
TNGRCIPQGS TYQCACNPGY QLSSDRRTCT RQAVNPCSPN PCDSTNGRCT PQGSTYQCAC
NAGYQLGADR RTCTPIARDP CSPNPCDPTN GRCIPQGSTY QCTCNPGFQL SSDRRTCTRQ
AVNPCSPNPC DPTNGRCIPQ GSTYQCTCNA GYQLGADRRT CTRQAVNPCS PNPCDPSNGR
CIPQGSTYQC TCNAGFQLGA DRRTCTRQAV NPCSPNPCDP TNGRCIPQGS TYQCACNAGY
QLGADRRTCT PPTPVIPQMA GVYHKALRIS VHVMLVISWE QTEGHVPDKQ STPAAPTPVI
PQTAGVYHKV LRTSVHVTLV INWEQIEEHV LDKQSTHAAP TLVIPEIVGV YHKALRTSVH
VTLVTSCLQT EGHVLDKQST PAAPTPVIPQ MAGVYHKAQH TSVHVTLVTS WEQTEEHVLV
KQSTPAAPTP VIPEMAGVYH KALRTSVHVT LVTRCLQTEG HVLDKQSTHA ALTPVIPQMA
DVLLRALCTS VCVTLAINCH RTEERVLDKS LTHVFPTPVI LPMVDVYLYK AFSTDVNVIQ
VFSCLQTAEH VFPYPHQIPV SQIHATESVD SAFHKDRRSG AHVVQGSSSW GMDGLVPSCG
ETPANLTHVT RPMPSVSQKE TTSDVYVGQD SSWLQTEGLV MPLLSPHYLI LVYRIPVIQS
MACVPRREET SGAPVGQGFS CYQMAGHVLQ WLYETLVYRT LVIQSMDSVS QREETSGAPV
GQGFGCYQMA GEIDPCENNN CDSVNGRCVP AYAAGGVVSF RCECNPGFAG DGIQCLRTTP
VDPCENNDCS ENGRCIPQGN SYTCECNPGF QGDGRTCTGI APPTDPCDDN DCDPNGRCIP
QGSSYTCECK DGFQGDGRTC TTINPCQVND CDLVNGHCVP QGGTYMCECN PGYSGNGRSC
TRISVDPCDG NDCDTENGFC VPQGNSYTCQ CRPGFQGDGR TCTRIAPADP CANNDCDPIN
GQCVPLGTPF TCICNAGFTL LADGKTCLRQ DPCLDNACDR NARCVEDASS PIGYQCVCND
GFLGNGFTCR VNDPCENNQC DPNANCVPAG DSYRCACKPG YQGSGFSCTE EDPCDANNCD
ANADCIREGS SFRCQCKPPF TGNGFTCTIP NMCIFQPCDI NADCISQPGS FSCRCRQGYQ
GDGHYCNPIP DPCSHPDCSP NAKCIPNMVT GEHTCECLPG YIGNGIVCTS NTIDPGPVDP
DNKDTDNNGT PPQCSTNDCD ANANCIAVGD GYSCVCKQGY VGDGRTCTEL DPCNPDPCGP
NAFCLKHGTQ WKCRCNKGFQ GEGDQCFVIE GPDPCRTSDC HPNANCLPTS SSYRCECRAG
YKGDGRLTCN PADPCDDNKC DRNAMCIPVG PRSYRCECKN GYQGNGFSCG AAVRYAPANW
LDPCASNEHD CDRDFGRCVY EGQGRYRCEC APGHAGDGRT CNAIAALPSP CEEGSHNCDE
NAVCINEGAG RYSCRCRPGL VGNGWTCYAT PVQPPANPCD RAACAPPGQG FCVPVSLTQY
RCECLPGFRD INGDGRVCQA IQPPGPQPTG NPCDRANCAP EGQAKCIPLG PTDYRCECLP
GYSGDGRVCT DMDECDLLDP ACDPNARCIN TFGSYRCECA PGFVGDGRTC SPVGQAPQAS
LLFAQGMSIS RIPVPAQGYR GQIVGSQSAA RGKKVLVKAG MTAVGIDYDC VDGYMYFTDV
TGRSISRAKM DGSQPEVIIS QGLSSPEGVA VDWISKNLYW TDSGTDVIEV SKLDGTNRRV
LFRDDLVNPR SIVVEPFSGT MYWTDWNRDK PKIVTANMDA TNRRTFVDSE IALPNGITID
YPANQLCWAD AGTKKVECAT LGTAANRRTV YTPTQYPFSM TSYQGRLFYT DWQRDAVLAI
NPQSQTEQGP LPLPLGSSGN PYGITTITNT CRRGANACSV RNGDCSHLCL PRPGNQRSCV
CPSNQYSNEA ACVE
//
