ID C3Y1H2_BRAFL Unreviewed; 1144 AA.
AC C3Y1H2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEN65712.1};
GN ORFNames=BRAFLDRAFT_102486 {ECO:0000313|EMBL:EEN65712.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN65712.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN65712.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN65712.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666480; EEN65712.1; -; Genomic_DNA.
DR RefSeq; XP_002609702.1; XM_002609656.1.
DR AlphaFoldDB; C3Y1H2; -.
DR STRING; 7739.C3Y1H2; -.
DR eggNOG; KOG1011; Eukaryota.
DR InParanoid; C3Y1H2; -.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR GO; GO:0061789; P:dense core granule priming; IBA:GO_Central.
DR GO; GO:0007528; P:neuromuscular junction development; IBA:GO_Central.
DR GO; GO:0099525; P:presynaptic dense core vesicle exocytosis; IBA:GO_Central.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0016081; P:synaptic vesicle docking; IBA:GO_Central.
DR GO; GO:0016188; P:synaptic vesicle maturation; IBA:GO_Central.
DR GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 43..93
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 150..274
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 582..725
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 835..977
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 992..1127
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 1144 AA; 130336 MW; DDF7E70357A1914C CRC64;
MKRQQGIHNA MATRSSLNDE ELKQHVYKKT LQALIYPISS TTPHNFEMWT ATTPTYCYEC
EGLLWGIARQ GVRCTECGVK CHEKCKDLLN ADCLQRAAEK ASSKHGAEDK TQNIISAMRD
RMKIRERNKP EIFELIKEVF SVDKTSHAGH MKAVKQSVLD GTSKWSAKLA ISVVSAQGLC
PKDKTGTSDP YVTVQVGRVK KRTRTVIQDL NPVWDEKFYF ECHNSSDRIK VRVWDEDDDF
KSRLKQKLSR ESDDFLGQTI IEVRTLSGEM DVWYNLDKRT DRSSVSGAIR LRISVEIKGE
EKVASYYAQY TCLHENLFHY LCEKNGGMYK IPDAKGDDAW KIYFDEPAQE IVDEFAMRYG
IESIYQAMTH FSCLCSKYMC PGVPALMSTL LANINAFYAH TSASTNVSAS DRFAASNFGK
ERFVKLLDQL HNSLRIDLSM YRNNFASSNP EKLGDLKSTV DLLTSITFFR MKVQELQSPP
RAGTVVKECV KACLKSTYQY IFDNCYELHE REFAPDKDKD KVPLEERGPS LKSLDFWTKL
INLVVSVIDE DKASYTPVLN QFPSELNVGE LSAATMWELF SQDIKFALEE HDQHRLCPVT
DYMNLHFRVK WLYIEYVAKV PPYKGTVPEY PRWFEPFVLL WLTENDKVSL EFLHGALDRD
RKDGFQQSSE HALFSCSVVD VFTQLNQSFD IIKKLECPDP EVTKHYMKRF AATVNTVLLE
YANIVQKEFD QYCAEEKKAC VLMNNIQQLR VQLEKVFESM GGDKLDPEAG DILKELQVKL
NNVLDELSQV FANSLEPQIK EAVVSMGNQL SKIKGAGNVS LNQPSARNNV AQEADVVIKP
LMDLLDKNLT LFAKVCEKTV LKRILKELWR IVMNTMEKTV VLPPLTDISG SQLLLSAAKE
LAHFSQFKQD MNQEDAKNLS PRQCAVLDSA LDTIKQYFHA GGNGLKKTFL EKSPDLQSLK
YALSLYTQTT DTLIKTFVQT QTQQDQPSVD DPQGEVSIQV DLFTHPGTGE HKVTVKVVAA
NDLKWQTTGM FRPFVEVNLI GPHLSDKRRK HSTKSKSNNW SPKYNETFHF ILGNEDDPMP
LNSTYLRDIV EAGSCACWCA LGRNVHLDET GWTILRILSQ RSNDEVAKEF VKLKSETRSD
MELG
//
