ID C3Y5C2_BRAFL Unreviewed; 1009 AA.
AC C3Y5C2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=mannosyl-oligosaccharide glucosidase {ECO:0000256|ARBA:ARBA00038888};
DE EC=3.2.1.106 {ECO:0000256|ARBA:ARBA00038888};
GN ORFNames=BRAFLDRAFT_125874 {ECO:0000313|EMBL:EEN64169.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN64169.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN64169.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN64169.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 63 family.
CC {ECO:0000256|ARBA:ARBA00010833}.
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DR EMBL; GG666487; EEN64169.1; -; Genomic_DNA.
DR RefSeq; XP_002608159.1; XM_002608113.1.
DR AlphaFoldDB; C3Y5C2; -.
DR STRING; 7739.C3Y5C2; -.
DR eggNOG; KOG0626; Eukaryota.
DR eggNOG; KOG2161; Eukaryota.
DR InParanoid; C3Y5C2; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0004573; F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity; IBA:GO_Central.
DR GO; GO:0009311; P:oligosaccharide metabolic process; IEA:InterPro.
DR GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.70.98.110; Glycosyl hydrolase family 63, N-terminal domain; 1.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR031335; Glyco_hydro_63_C.
DR InterPro; IPR038518; Glyco_hydro_63N_sf.
DR InterPro; IPR004888; Glycoside_hydrolase_63.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR PANTHER; PTHR10412; MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE; 1.
DR PANTHER; PTHR10412:SF11; MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE; 1.
DR Pfam; PF00232; Glyco_hydro_1; 1.
DR Pfam; PF03200; Glyco_hydro_63; 1.
DR Pfam; PF12470; SUFU_C; 2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 297..333
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT DOMAIN 340..369
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT DOMAIN 512..1007
FT /note="Glycosyl hydrolase family 63 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03200"
FT REGION 713..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 115250 MW; AFC18E9240D82E3D CRC64;
MVHCAHYDYG EYDRTRDDFR PGTFPDGFIW STATASYQIE GAWNVDGKGE SIWDRFSHTP
GKVDRGDTGD VACDSHNKYR EDVQLMKAMG LKYYRFSLSW PRIFPDGTVA GGVNQAGVDY
YNNVIDELLA NGITPMVTLY HWDLPQALQD RYGGWVNEEI VEHYDNYATF AFQTFGDRVK
YWLTFNEPMV LCSLGYTSGE HAPGIHDPTS VSGLSCGHTL LKAHARAWHT YNTTFRQLQG
GKVGIALSLL WAEPRDPDLP ADVSATDRAM QMINGWFAQP IFGDGDYPNV IKETEVVERG
IETEGSNLSG VSAKCSWEEM EESREEREES EETVRQRITP HAITFVSPRV MGAIADESHP
YASRGPWLQK SKSISIPTVS FLFYAATDGQ GTIQPVLENN RLVAITGQTE ELGKFRMSFP
KVSRKNITYH HLVSYSPRLD LLKSSVEHGM RRLLFNKTRI QYGLAGDLIK RSNMPDLKAN
VLVHQVTLEV PCVLEVVFES ESFTSRNTRL VGMELTRELE KYKVAFDEKF ENTFGLNRRG
YTEKNLRFAK AAVSNMVGGI GYFRGKSLVQ SPYNEEPVEY WEAPLYTAVP SRSFFPRGFL
WDEGFHQLLI SKWDTAISKE ILSHWLDLMN MEGWIPREQI LGSEARSKVP AEFVVQKNQN
ANPPTLFLPI QSLMKDLASN RSEEDILLLK RMFPRLKTWY NWFNTSQLGN EPSSYRWRGR
DPGANKNQQL NPLTLTSGLD DYPRASHPSD SERHIDLRCW MALASGVMAD IAKVIGEPGE
EYEATHKLLT DNALLEKLHW SPEKQLFSDY GKHTKGVVLE REKVPLPPPP KPGMRRQPVP
KGKMYRVLKG EQPTDKFVNS FGYVSLFPFL LQIVDPKSPK LGKILTDLKN PQLLWTKYGL
RSLAKTDPLY MKYNTEHDPP YWRGQIWINM NFLAVRALHH YSNIKGPYQS QAADTYKELR
RSLIHNLYVE YERSGFIWEN YSDVNGHGKG CHPFTGWSSL IVLIMAEKY
//
