ID C3Y777_BRAFL Unreviewed; 469 AA.
AC C3Y777;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
GN ORFNames=BRAFLDRAFT_123266 {ECO:0000313|EMBL:EEN63705.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN63705.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN63705.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN63705.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
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DR EMBL; GG666489; EEN63705.1; -; Genomic_DNA.
DR RefSeq; XP_002607695.1; XM_002607649.1.
DR AlphaFoldDB; C3Y777; -.
DR STRING; 7739.C3Y777; -.
DR eggNOG; ENOG502SERZ; Eukaryota.
DR InParanoid; C3Y777; -.
DR UniPathway; UPA00628; -.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
SQ SEQUENCE 469 AA; 52267 MW; 3935EC539F2B6F3C CRC64;
MPMVQCMLDP CDVATCPGNP RARCEHNFCG GCNAVFYDKT GAMADCNGDG CPDDKPMARC
MMDPCDVTSC SANPDATCVA DYCGGCNANF FDRSGEPAWG SKGIPMKNIK MLGDLELIGW
GIRASLDSDI MDSVWVSTDH DDIAAVASRC GAQVHRRSSQ VSHDKCNSWT AIDEFVRNHM
DVDIIVHIQA TCPCVHPFHI QEGVRMMLQD GKDSVFSVYR RHQLRWSTPR YGMQAYPLNF
DVYDRPRRQE WPGELIENGA FYMFTRDVEQ QGVLQGGRMG CLVMDSEYSI DIDTDQDWQL
AEQRLLRFGY HGRAPKKMKL VVVNIDGTLL DGKVQVSSTG EEYRSFKATD IAGIQMLQRN
GIEFRVVAQG ESQVQKELAK KLSLKLEENC EKSGMSGCPS DADTEVQKHS HVVSIYRGGQ
GALREFCEQL LLKCGVEPTL EARNETGNFK VSSRVIQKDQ VSSQPEMPS
//
