ID C3Y9E2_BRAFL Unreviewed; 519 AA.
AC C3Y9E2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN ORFNames=BRAFLDRAFT_118634 {ECO:0000313|EMBL:EEN63198.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN63198.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN63198.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN63198.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361114}.
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DR EMBL; GG666492; EEN63198.1; -; Genomic_DNA.
DR RefSeq; XP_002607188.1; XM_002607142.1.
DR AlphaFoldDB; C3Y9E2; -.
DR STRING; 7739.C3Y9E2; -.
DR eggNOG; KOG4433; Eukaryota.
DR InParanoid; C3Y9E2; -.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IBA:GO_Central.
DR GO; GO:0072320; F:volume-sensitive chloride channel activity; IBA:GO_Central.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF8; PROTEIN TWEETY; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 43..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 233..258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 385..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 57887 MW; 2B014D9CEA31981C CRC64;
MATKNYTVPT LAKWFNSFPH YNLQFLQINN TFSPEESDYQ EALGFWAAVP AAWLTVTLFF
FLVYFCARCC SNGTARKHPA YCLRWTIGIL SLIALTGVAI GLYGNVEANQ GVHDFATATE
SANKTITGVE TQVNVMNSGL TDMMSPLDRL RDLVTEIPGA EKIINDTIAE VKKLVSELGT
IPFDQEGVNL QLIADDTRFY EYYRFMGTVL LLVLEIVVGL VALCGVGRGS RCLLIFMTCL
AFLCLFVCFG GGAVYLAAGV TISRGRDGVS QAKDFLREVE GLTTNLPGAK EPHLQQRTYG
PLPQVSAVVR SQRLRLAGHV VRHEEMAGQV LLWEPNEPRR RGRPSATLRK LMLEETGLEA
NELRSVMLDR NEWRHRKQYI EIDEEDPFLP PSGMTPTMNR TSQGPLDHYL RGGDRGEREP
LMRDNRTPPP SNMPVLDYGD CPYCCPASGS LTPASATSHP SPVESEDSDD DEELEAATIE
QRGLTRERKY QDTLAAVKDK MLVNMRPVPV RLDFEPDNH
//
