ID C3YC48_BRAFL Unreviewed; 3498 AA.
AC C3YC48;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_92090 {ECO:0000313|EMBL:EEN62080.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN62080.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN62080.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN62080.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG666500; EEN62080.1; -; Genomic_DNA.
DR RefSeq; XP_002606070.1; XM_002606024.1.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; C3YC48; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IBA:GO_Central.
DR CDD; cd00033; CCP; 9.
DR CDD; cd00054; EGF_CA; 21.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 11.
DR Gene3D; 2.10.25.10; Laminin; 23.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR45836:SF13; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 14.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF02494; HYR; 6.
DR Pfam; PF13385; Laminin_G_3; 2.
DR Pfam; PF00084; Sushi; 9.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00032; CCP; 13.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 24.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SMART; SM00274; FOLN; 3.
DR SMART; SM00159; PTX; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 11.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 15.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 15.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 17.
DR PROSITE; PS50026; EGF_3; 23.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50825; HYR; 6.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
DR PROSITE; PS50923; SUSHI; 12.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DOMAIN 76..161
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 162..227
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 228..294
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 295..359
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 360..426
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 427..495
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 494..579
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 580..654
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 655..717
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 718..781
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 780..866
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 867..929
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 930..996
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 995..1076
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 1077..1139
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1138..1222
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 1223..1305
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 1306..1369
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1685..1721
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1723..1759
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1761..1797
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1799..1835
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1837..1873
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1875..1911
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1913..1951
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1953..1989
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1991..2027
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2029..2065
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2067..2103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2105..2141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2143..2179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2181..2217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2219..2255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2257..2293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2295..2331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2333..2388
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2390..2426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2428..2464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2466..2502
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2714..2750
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2752..2790
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3257..3345
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DISULFID 230..273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 330..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 466..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1711..1720
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1749..1758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1787..1796
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1825..1834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1863..1872
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1901..1910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1922..1939
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1941..1950
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1979..1988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2017..2026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2055..2064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2093..2102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2131..2140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2169..2178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2207..2216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2245..2254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2283..2292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2321..2330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2378..2387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2416..2425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2454..2463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2492..2501
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2740..2749
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2761..2778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2780..2789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3498 AA; 374494 MW; 56B6CCB50A8232EE CRC64;
MTKSNQQKNG PLDHGDINKT HFHPPEFFIE WRKQICPLEG EPTFRGAWRR RRRRRYYVYP
VVQPAVVQIV TPTPTRDVEA PTFPNCPSPI SAQAEKGTVS AFVSWAAPGA EDNSGEDVHV
SQTVGQPPGS RFEEGFHTIV YTATDSVMNS ANCSFTVTVT TPKCSRLQTL QYASILCDNQ
YNYGSTCTYT CDEGYFLNGD PTTTCELDLS TDATYWTHSA SQHNCQPVQC PQLPSIQNGG
WLVNTTCSNT FGSYCYFQCD PGYKLQGDST VSCKASTPGQ STGVWDGNIP TCIESTCSPL
GPIANGRIVF DQDCPFGNVF SAGSVCGVSC SPGHVLIGSS FLTCLLDGTW NASLPSCEVI
TCDSAGLPTP TNGYKLGCSN SEEPHGTTCI LGCNTGYEPA IPVQRTCIAD GNGVGQWSNG
TINCKEIKCR HLPKPNNGNI TACYHDGVRT EPEQSQSVGA VCSTMCNEGY TAAGSAERTC
LPGGGWNGTE LRCRDLAPPV LQCPDEIILV ANEGQDTATV DWHWEPVLAN DAGKDIVSAL
SGSTTRETEL PEGRHFFTYE ATDAAGNRAS CTMAIDVRVI RCPGLPSVVN GVTTLVAGKG
TCSGGSVRGS QCEVTCDAGY SMADGSTVTT RTCHRTGNDT LQASWTGPVP VCTGVTCPLP
TLVNGFVFGC NPPEAIYGAS CEFHCNRGYK GPANETAVTR TCRGNGTFTG EPLLCHPIKC
SGLPTVENGM VIPATCLSPS VSNGEICIFN CDPGYSIMGP FSKQCLTDGR WSDTRKTSCK
DHEPPRFTGQ CPTYVNAIGD AGKTSATVLF TEPAATDNSN YVNVSRAANQ RGPGDDFPEG
TTVVTYVAKD AANNRAQCDV FVVVRVHRCP MVQAPASGAV NCSGDFYGSK CQYRCNEGYM
LDGSPFRHCV LSADGSSSYW NGSQPVCRGA SCSPLALPGD VSATPSSCQV SPDVGDTCIL
SCSRTGYRLT PQSGQFVICL GDGQWSSNVS SLVCSDIEKP RFSQCPQDQM FYADRGSQST
FVNWTVSAID NSGEIPTVTC SQSPAVLPAG DYQVSCTATD ATGNTETCLF DVRVKVRRCQ
QLLPPLYGSF VGTCDTAYGS TCQVTCTAGY QLEGSDTATC EMQGNNAVWD RATNPVCQDI
TAPTLLTCPG PQYGTITDSS FLGVSVSFDI PRATDNSGET LSITKLPVDI TSPYNFTADT
VVTYEFRDSG GNSVTCTFMV YIKGELPPNV VFCPDDLTIT ATDRLAEVSW PEPVFDDPTG
GDLDVSANIA NNGSLPWGDH SVTYTATNVD NGKSVTCTFL VIVRPVACPP LNPPLHGALA
CDTWVYGKFC SMFCSAQYDI PRGSNPGDKY ICGASGIWSP PPPVPDCVSS FRPNRFVLPS
ELHYFSGDCS DPSVQADIAQ RFVTILNGSD FGSACSDSVG CSWENVEVVC GANSRRRSLG
RQSKLVTGQM TDISSRSSGQ YLLTMKFSLV VNMTDDDPNL SSVDRYYAAD DQLLMMTDVI
QAEIYSGDFD VSVPGLSLQV DQNSLTYGWS ELDCPKGYAE QPDSMNCGVY LLVVISLFRW
YCNLIGVFDY PGYPECVGCP TGTFYDEDAD DCLKCSVGYY QDEEGQFQCK TCPLGTSTID
EGARNLTECL DLCPPGSYSN TRVVPCTKCD IGYYQDQEGH TICNRCNASF STLTIGSSSE
SDCKELDACV SNPCGNGGVC NRLIDGYTCV CLSGFIGDNC EVNIDDCARN PCLNNGTCVD
GIDTYSCVCS QGYTGNTCEE DIDDCQHLPC LNNGACEDLV GSFICHCQPG FMGATCEITV
DACYHHECKN SATCVSQDTS YECVCPNGFT GDLCETNIDD CRGNPCLHNG VCVDGVMDFT
CLCTMGYTGS LCEVDVDLCD SGPCLNSGTC VDLGDDFACQ CVEGLSGKTC ESPRDPCSVQ
PCLNGGSCTV QPQTGDYVCS CAQGFAGIQC EIDIDECASG PCSNDAICLD GINQYSCACT
NGFVGHNCEE AVDHCASSPC GNNSTCLSER DGYRCICPPT ATGPTCGTPV DLCTSSPCVN
NGSCVVDGNG YTCYCSPDFT GPTCDTEEDS CEDDPCANGG LCTDGFGTFS CACPDGYTGL
TCEQEINECT SNPCQNSGVC VDKEAGYDCL CPKGTSGNHC EENFDDCHNV TCLNGGSCID
LVSAFLCNCS PGYEGKFCES EINECNIYPC RNARSCRDLL NDYECECEPG WTGKNCETNI
DDCFPNPCGN GGVCHDRVNS YTCSCLGGFS GLHCEVNIDE CMEVQCENNG TCVDGVGTAS
CVCGLGWTGT NCQVEIDECS LEPCMNGGGC VDTIGSFVCN CVDGFTGRLC EEDINDCDIP
RCMNGGTCVD QVNGIIYEAF TCNVRGPVVK VARYMCRCPP GYTGTNCEVN INECSSQPCR
NGGQCIDESD GFICVCPQGF SGRTCDVNID DCIPNMCENG ATCLDGIGDY TCICKLGFSG
RRCEVDVDDC ASRPCENTAT CLDGVNEYTC LCPPGYSGVR CEYALPTDFD IHVTSSDSNH
YSEVSKQNIH SMSAIAWWMR VMDAPNNYAP VTVAVTRNNS DAREPLFIVQ NPNRIELVLS
GTIIQSSVNC ADGGWHHVAV SYEPASEVLA LYVDGMMENT TRVPSLQNSS PADGFVVSVA
TGVTNANIGD SAFQGEISQL NAWARELSQS EIVELSSTCQ TVAVGDAVAW SDFVDATQTD
PQYGAISSPS VCDSEDQCES SPCLNGGTCR DGYLTFTCTC PHSHVGQRCE TQLNPCDGNL
CQNGAACVAD VTSMTYTCSC PEGCSGDLCN VLSVNGGWSE WSQWSACTAT CGNSTRSRQR
LCNNPPPLGG GNPCTGVSLE TEACVNIPDC TRCTELRHPE NGYLVCSPDG VDTKCEVHCR
AGFMMVVNPD LYVNLRCGPS TWYTWTHQDL TNLPARIPGC TKKELPTSVT VDYVICYKNV
SEDPFATLFT QQILGPSASF LNEQTYEHAF DSVVTRNLLS LDCITSRNCH KDGSEVRFDN
VTTGNNTRLD VVGHIFMSTQ VPQVSDPVLT LAQSSKYSFP MDVISGGFVA GNPALTSVGN
LSLIDGISGK AISLDGQAQY LNAGQFPGEC LGSSVYCPNG YTITAWLRVN SVPSSPSHDV
YYLSNGGQTS SSRGFAVGYK GGFFARVSFD SRYRSLAFSV DLHTWFNTAL TWSPGGDPTL
YINGTLVNAT VTDGSLSALT SDTRTQFLVG APNNIDNPSS GHLGHTDVDD VLFWDRVLTQ
EEIRDLMSAE PVAVARICRG QHLTLSCEPE EVITIHSATF KVSTPSECGA LDSSQIDSCV
DDAALEFTLN LCDGQRSCHL HATDEVFGND CVETRNSFEV LYTCDTGRFN DKDIIMENIE
QDWETTLKSL SQMVENGDFD LNVLHQDIPA DKNNTEEIEI QLTCTGNMVG MGLCDACFPG
SFYNGRECVP CPQGQFQSPT TPTKCESCPP GYTTVGFGSV DVTACYVYTC TCDFSVRTTD
PDLQGNVRFK FRSVRACG
//
