ID C3YFU1_BRAFL Unreviewed; 510 AA.
AC C3YFU1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN ORFNames=BRAFLDRAFT_80288 {ECO:0000313|EMBL:EEN60746.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN60746.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN60746.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN60746.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; GG666510; EEN60746.1; -; Genomic_DNA.
DR RefSeq; XP_002604736.1; XM_002604690.1.
DR AlphaFoldDB; C3YFU1; -.
DR STRING; 7739.C3YFU1; -.
DR eggNOG; KOG3703; Eukaryota.
DR InParanoid; C3YFU1; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IBA:GO_Central.
DR GO; GO:0019213; F:deacetylase activity; IBA:GO_Central.
DR GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IBA:GO_Central.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF56; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..510
FT /note="Sulfotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002933696"
FT DOMAIN 43..222
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 312..492
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 321
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 419
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
SQ SEQUENCE 510 AA; 59482 MW; 36E22F8E361AF1A1 CRC64;
MAPVLSELVH WLVCLANECL KIWSRAGGQE AIFATFGYMD CDNALISAQS RLGSLVPGFR
FNLGFSGYFY HSGDDIEDIG DDALLANAHE FWWFPHMWAH TQPHTFTNET SLREQMILNK
RFAKEHGIPT DGGYAVAPHH SGVYPVHVPL YEAWRKVWGI KVTSTEEYPH LRPPRHRRGF
IYKNIVVLPR QTCGLFTHTI FIDKYPGGRS RLEESIHGGE LFQTFINSRV NIFMTHLSNY
GNDRLALYTF ESVIKFVQCW TNLQLKTVPP MELGRKYFDL YPEEANPVWQ NPCDDKRHLA
IWSKYKTCDR LPRFLVIGPQ KTGTTALYAF LSMHPNILSN FPSSKTFEEV QFFNGANYYR
GIDWYMEFFP TPSNSSLQYL FEKSATYFDN ELVPKRAHAL LPRAKIVTIL INPARRAYSW
YQLLILDGDQ LRTDPVSTMW KTQKFLKVKP HFDYDSHLRY ILEIHLLILD GDQLRTDPVS
TMWKTQKFLK VKPHFDYDSH LRYILEIHVC
//