ID C3YN18_BRAFL Unreviewed; 396 AA.
AC C3YN18;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=General transcription factor IIH subunit {ECO:0000256|PIRNR:PIRNR015919};
GN Name=LOC118430593 {ECO:0000313|RefSeq:XP_035697454.1,
GN ECO:0000313|RefSeq:XP_035697455.1};
GN ORFNames=BRAFLDRAFT_282199 {ECO:0000313|EMBL:EEN58337.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN58337.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN58337.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN58337.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000313|RefSeq:XP_035697454.1, ECO:0000313|RefSeq:XP_035697455.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035697454.1,
RC ECO:0000313|RefSeq:XP_035697455.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035697454.1,
RC ECO:0000313|RefSeq:XP_035697455.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR015919}.
CC -!- SIMILARITY: Belongs to the GTF2H2 family.
CC {ECO:0000256|ARBA:ARBA00006092, ECO:0000256|PIRNR:PIRNR015919}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666532; EEN58337.1; -; Genomic_DNA.
DR RefSeq; XP_002602325.1; XM_002602279.1.
DR RefSeq; XP_035697454.1; XM_035841561.1.
DR RefSeq; XP_035697455.1; XM_035841562.1.
DR STRING; 7739.C3YN18; -.
DR KEGG; bfo:118430593; -.
DR eggNOG; KOG2807; Eukaryota.
DR InParanoid; C3YN18; -.
DR OMA; INWVEVP; -.
DR OrthoDB; 276422at2759; -.
DR Proteomes; UP000001554; Chromosome 14.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd01453; vWA_transcription_factor_IIH_type; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR007198; Ssl1-like.
DR InterPro; IPR004595; TFIIH_C1-like_dom.
DR InterPro; IPR012170; TFIIH_SSL1/p44.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR NCBIfam; TIGR00622; ssl1; 1.
DR PANTHER; PTHR12695; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2; 1.
DR PANTHER; PTHR12695:SF2; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED; 1.
DR Pfam; PF07975; C1_4; 1.
DR Pfam; PF04056; Ssl1; 1.
DR PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR SMART; SM01047; C1_4; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR015919};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015919};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 61..217
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 359..382
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT ZN_FING 290..307
FT /note="C4-type"
FT /evidence="ECO:0000256|PIRSR:PIRSR015919-1"
SQ SEQUENCE 396 AA; 44642 MW; 6D74C7DA6604D3F6 CRC64;
MADEDVEKTY RWEGDYEKTW EVLQEDAAGS LQASVDDIIH RAKRRRLQDR QVNVRLGMMR
HLFVVVDMSQ SMEDQDLKPT RILVTLKLLE NFIEEYFDQN PISQLGVITT KNKRAEKLTE
LGGNPKRHVT QLRTLSSASC VGEPSIMNSL DLAAQTLKHM PTHTSREVLI IMGSLTTCDP
GDINITMKMV KDLNIRCSVI GLAAEVQVCK KLCNMTNGTY GIILEDTHFK DLLLEHCTPP
PATVNTDSSL IKMGFPQHTI SQDHDSVKPS MCMCHQDTEA QSFTPSGYFC PQCHAKYCEL
PVECKICGLT LVSAPHLARS YHHFFPLENF REIPLEELDA ELSRFCTGCQ VQLNGPVVYC
CTRCSRPFCI DCDLFIHETL HSCPGCINKR IGPNSS
//
