ID   C3YN65_BRAFL            Unreviewed;      1102 AA.
AC   C3YN65;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   22-FEB-2023, entry version 57.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN   ORFNames=BRAFLDRAFT_97974 {ECO:0000313|EMBL:EEN58171.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN58171.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN58171.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN58171.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
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DR   EMBL; GG666533; EEN58171.1; -; Genomic_DNA.
DR   RefSeq; XP_002602159.1; XM_002602113.1.
DR   AlphaFoldDB; C3YN65; -.
DR   eggNOG; ENOG502QWRJ; Eukaryota.
DR   InParanoid; C3YN65; -.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46312; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46312:SF1; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13516; LRR_6; 4.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00367; LRR_CC; 6.
DR   SMART; SM00368; LRR_RI; 6.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
FT   DOMAIN          78..161
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          35..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  123907 MW;  24BF0F1EFF5011A2 CRC64;
     MAKVVENGQN GQSGREWSEW PEWWRMVRMT RVVENGQNGQ SDGECSQRKR KEEDGREFPV
     KKKSASCRED LSTPVGDVRK YFYYIREHVS SDWKDLAFHL GFWWSDVSNI EGRNRDDKSR
     CMDLLEEWLK RNGERATIEV LMEALIKADL QSVVDGLKQK EFPGVPCPFE AAGTESSSLT
     DIFRMNVKKY YELRLTHFKP LIWDDNFTLT ISDIFTQLEL IPTAKRTGNR SESDREEQMK
     ELKSLEDLFK PDITGQLTAP RCILIEGEAG GGKTTFLSKE ALDAVSQKTE LGRRHSIILL
     IRLREVRVGE TIEEMVWDQC VYETTENGYD ELQPEARAAG QAIPKLLSGK LYPYSTIVIT
     SRPSAGVQEY TRPDCHVRIM GFSHRHLEAY MQQYFTVVGK QELARNLAVH VQDNELLNTL
     IQTPIFLMLV CALWAKDQEM VSAGTMTGLY DNLLICLVRK YCKREGVNMP TEGLPTEVAE
     SLLQLGKLAL QALLRNDTLL DLTEVEKEKV NWVLLLKLGV VSLEVSSSRL YPLIPRKQLS
     FPHKTMQEFL AGRYVAHASG SQDIVELLQL TSITKVFELS NLLQFTCGCE SQVAQAVMEE
     LCYLSDEEFS HLQPDDFHKS HLPVKSEVQK SVETYKRFVL LCLKVLNERK EQEILQAVSK
     ALPVVILDIN RMKKQHTTFK YYLENIQPLH FPDRMILELS FFRSAEDLQY LEKTFPSAIP
     GLQLDLRLRY MMFGSPDKTA WLVSVLKNVP GLRVLDLSDI ATLLTPSSLQ PLVQGFSHMS
     LLEELDLSWN PELGDAGMEV LQVGLPSLPH LAVLRLARVG ITALGMSFLA PYMGNLLRLT
     ELDITCNEIG NTGLEFLISV LPIFTAMQVL VLSDIRIGVT GMRTLVPVLC QLTRLIKLDI
     SNNAIGDLGL ECLAAILHHL TAMKVLVLSE TGISDRGVSS LIKALPHLVR LQVLNLSDND
     IGDIGIVSLV QSLATAPHDP CNITLQELYI SWNTGVTGAG LGRVTQLISK LPALTRLDMS
     GHADTPSHLS NTAAMDLTEA LPRLPNLEEL NLFYISMEPA GFNAVVQAAD GHPTLKELHY
     ETEQVPEGAE TTASYLKLSS FQ
//