ID   C3YNM8_BRAFL            Unreviewed;       207 AA.
AC   C3YNM8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Dickkopf N-terminal cysteine-rich domain-containing protein {ECO:0000259|Pfam:PF04706};
GN   ORFNames=BRAFLDRAFT_98960 {ECO:0000313|EMBL:EEN58123.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN58123.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN58123.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN58123.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC       {ECO:0000256|ARBA:ARBA00010842}.
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DR   EMBL; GG666534; EEN58123.1; -; Genomic_DNA.
DR   RefSeq; XP_002602111.1; XM_002602065.1.
DR   AlphaFoldDB; C3YNM8; -.
DR   eggNOG; ENOG502RZFU; Eukaryota.
DR   InParanoid; C3YNM8; -.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0039706; F:co-receptor binding; IBA:GO_Central.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK1-4.
DR   PANTHER; PTHR12113:SF31; DICKKOPF-RELATED PROTEIN 3-LIKE; 1.
DR   PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..207
FT                   /note="Dickkopf N-terminal cysteine-rich domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002935894"
FT   DOMAIN          66..113
FT                   /note="Dickkopf N-terminal cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF04706"
SQ   SEQUENCE   207 AA;  23159 MW;  04516EA95037EDA2 CRC64;
     MLPRAVLTLV SLFSTLPVCP GYLFGYSWGV PVPNHQDFTN HPRNILDRAD NATENRTRTL
     DSAVPCDTDK SCGGGKYCDR HYGVCKPRGR LGDLCRRDGN CQGGYDCMFG RCQKTIQAGE
     QGARCKHDKD CGDNMCCARQ HGERICKPRL APGQKCWVPE GGLDYSLNQM CPCEKGLICG
     EVQTPPREEE FVLWTDNHHM RCKAIDE
//