ID C3YPV0_BRAFL Unreviewed; 1337 AA.
AC C3YPV0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=BRAFLDRAFT_75911 {ECO:0000313|EMBL:EEN57884.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN57884.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN57884.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN57884.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG666538; EEN57884.1; -; Genomic_DNA.
DR RefSeq; XP_002601872.1; XM_002601826.1.
DR eggNOG; KOG0507; Eukaryota.
DR eggNOG; KOG2571; Eukaryota.
DR InParanoid; C3YPV0; -.
DR GO; GO:0071944; C:cell periphery; IBA:GO_Central.
DR GO; GO:0030428; C:cell septum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IBA:GO_Central.
DR GO; GO:0006038; P:cell wall chitin biosynthetic process; IBA:GO_Central.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF41; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 2.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1110..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1145..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1223..1279
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1292..1337
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1337 AA; 150466 MW; 3AC610D6C14DD65D CRC64;
MATPANNNNP SRTRSYSHDL EITLTVGGSQ PESPPPSAEE EEEPEEEITS KYPVWAHVLK
ILFSFFIFLT VLTCACASKT ALVILLQGNT TNNGPGVEKT LKEESEVKED GGSVKETMVT
ETMVTQTRLM ESARVVMVGL LLVVPQVFTV LRCITCSSFG KKTNTYPWPT WRALILGLVC
SVVEVTCLTV FCFDIAPSLD PPVLVLVMSG TVGVQLFEDA VKSIRTRHHS FPNDFNLTRK
IEKFLKFISG FANVAAVCAI ATLVFLKENS LELYQGITLP FIILLLSAAW SKFAHKQMSK
PHLLRTLPYE EHLYSARFKA TLLSSFFKVV LTPLAIVVYN YVLFNRGFEI YSEGFTQMSS
SPLLVPFLIQ LFGSFLGYLA AWLACSTCIQ LVGFVIPLLL CTPAAIALTF SICNLPILDL
NLFRCYDMST EQQWILIGTC ALLWVTQAAY LLFVVRKSPT RTLSKEETLF YRPFYNGIFL
EQNLLLNRRK EWPSAEREEE EHLQTAAKHG GRVYVCTTMY RESEQEMSQL LHSIYRLSRV
YSTSKWRYES HIFLDGGVRG LVLNEFALLL VSLLDEKLDI TPADARKMET PYGVQLWWKL
PGGMPFYIHM KDPEKVKQKK RWSQVMYLSY ILDLRQKELL QPAYTQRPPS PSFMSVEGDE
ESEIDNELAT QDSNTPPLGD EGFHDSNEHQ APGSRNMTAT PYFSPVSDND DSTTPDTRTD
DEYFTVAEGE SSWEDGRDHA SDTDSLPPRY DGQHYRRLPV LPHHIDQLDD ETFVLTTDAD
VQFTPESVAA LLDLASRDRK VGAVSGRTHP SGTGPVVWYQ IFDYAIGHWF QKVAEHVYGS
VLCCPGCFSV FRARALRQDM GEDRWLSTLL VEKGWRLEYG AVAECKTFCP DTLEEFFKQR
RRWIPSTLAN LLLLLKYTRK IARNNDSFSL FYALYVSLLL LSSLIAPATV LFIIAGGLQY
SINLESYQTL LLMSAIVFIY MLICVWGSGK TQLLASKVMT FFFAVVMVGV ATGLAISVVE
DFEPEPTSPP PPTEAPIITM APTSDGQQLS LLLSGRFQQT TVPNHLPFQL TTVPDDLTLT
SVSSDLLGAF VDQQYQQFFA ANNNGTSADF LPASVSTLYL GVLAAVHLVA AILHPTEFAC
IIPGLLYVLC LPSAYLVLFI YSICNLNDRS WGTRESAHDR SQSTRGETTS GQDQDLDNEV
NTMYSDIDRT GGEDTFRRKA IPWLKDIGMK RYEKEFLDNG YEDTSFICTI KEEDLRFMGI
RMRGHVMKLT RAISQLPEPI LPTGRQVGLD TWLRDLGLAQ YYFRFIEGGY SGVHGMEHLR
GMTAQDLQEI GITKRGK
//
