ID   C3YTV7_BRAFL            Unreviewed;       818 AA.
AC   C3YTV7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=BRAFLDRAFT_118263 {ECO:0000313|EMBL:EEN56234.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN56234.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN56234.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN56234.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; GG666552; EEN56234.1; -; Genomic_DNA.
DR   RefSeq; XP_002600222.1; XM_002600176.1.
DR   AlphaFoldDB; C3YTV7; -.
DR   STRING; 7739.C3YTV7; -.
DR   eggNOG; KOG2165; Eukaryota.
DR   InParanoid; C3YTV7; -.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          476..700
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          165..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..190
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  92940 MW;  A3339F9BF5212B8D CRC64;
     MAASVENLGA AWSTVTTGLL PCRGQAKAPP TDDVLKSAIS VLDHHGVSFI IEEWFLESLQ
     SDLRENIGPT FWDHFSAETN GPKQHGADGT LVSAFSELHT SLSSYLPSVD VLERLRTEGS
     KQSLKDKVLL IFKALLFYDI PLKFHGVVKE FYSCAFKACE EELRKKEKTS PGEEDGPDDE
     EEDTDEDSLT CGGCEQEKER CSCTETLTLF HQLNAQLHSL GLLERVCGEA VTAIIHDRIQ
     QHIQNTCQGE FESQFLHPLE KWLNSKVLSW LHLVFKGSPG QTGEREVSAK TQESLDRWQT
     RLLYFLYQTY GTLRISEMFD IIVEFPDSMS ALEDLKVCLE KTDLRRTLVS SLRSAIGRRL
     LQPGATTSDV LSQYILLVKS LRVLDPTGVL LELVGDRIRH YLRTRDDTVR KIVEGLTEEE
     GGSDLADELM KGDPISLEEG VEEEGEDPWA WTKWEPDPID ADPSKTSKSR RSPDIISLLI
     SIYGSKELFI KEYQSVLCNR ILSFNYDLTR ELRNLELLKL RFGESQLGNC EVMLKDVQDS
     KRVNDLIKSE NLMELQDSLC SVLLSSMTVG HYVGYPLVRF NRVFPQQGVA VSGMIISAQY
     WPQLKETKLA LPPAVQQRFD SYTQAFQTVK ASRTLNWLPQ MGLVDLDIEL KNRRLSVMVN
     PVVATIIMHF QDKERWTLDE LSTAMQVPSS VLRRRITFWQ NYGLIRENPP GTYVLLEEGA
     DHHGDVMIDS DEETESATAS SQEMREEEMQ MFWVYVQGML TNLDSLPLER IHSMLKMFAM
     RDNPIEISLQ ELKAFLDSKV RSQQLLLSGG KYKLPKNR
//