ID   C3YUG3_BRAFL            Unreviewed;      1096 AA.
AC   C3YUG3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   ORFNames=BRAFLDRAFT_79673 {ECO:0000313|EMBL:EEN56083.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN56083.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN56083.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN56083.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the CLCR family.
CC       {ECO:0000256|ARBA:ARBA00006398}.
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DR   EMBL; GG666553; EEN56083.1; -; Genomic_DNA.
DR   RefSeq; XP_002600071.1; XM_002600025.1.
DR   AlphaFoldDB; C3YUG3; -.
DR   STRING; 7739.C3YUG3; -.
DR   eggNOG; ENOG502QRRD; Eukaryota.
DR   InParanoid; C3YUG3; -.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013642; CLCA_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF08434; CLCA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          166..353
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          382..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          839..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          884..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          934..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1028..1061
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..863
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        890..913
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1028..1046
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1047..1061
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1096 AA;  119312 MW;  322480B836368603 CRC64;
     MPACRVLVHE WGHLRWGLFD EYASEDANAF YIHENGEVQA TRCSLAIRGA YRHKDTREEC
     RRDPTTALYE AGCRFEVDRN STDATGSIMY APYLDTVFEF CHGNESGDPL SYHNSQAPSP
     QNLRCGGRSA WDVMLEHPDF AGGANRPDLS PYAEPNFSVV RSTDRRVVLV LDVSGSMTGQ
     GRMERLRRSV STYILSTIED GAWLGIVTFR GTSHKICDLE QLNGDSVREE ILNMTLDGLT
     NRTGKVGTNI TRAVTLAVQI LGPAVQDRKL GDSTGPRQMI LITDGRDRRL NNSVIFMLQN
     DTAKGVVIDT IALGDGAEEG LPLLSEVTGG QFFFSPDSDA GGSALDDALT ATVLKYVDDD
     STSVPVSAGR WHITIQNEAT RSKRDTTTQS IQIDVTSKPD DPDNPTITLT CHLSNHHVIL
     GESPDVIAVR ADLRKGYTPV LSAGVAAIVE STSGNATNIP LLDNGVDDVE VEIVQVSLEQ
     FQRKTSGGAI VIEVPQTYVQ ADHLDVNPSA ITDLRVSSVS NQDKTITLSW TAVGDDYTYG
     TASYYDIRMS DSLSGILSNL EDASRILQEN VKTGNLSAPR EAGQKETFTI SLPDVTENAT
     LYISVRAIDV SGNAGSPSRP VVVSLIYIPP LEPSTAAPDD WPTGLPLPAT VPSSPVEATV
     SATYLAAGVA AGTLVVLSVV IVLKSVAKRY QASKGKSQKF VPDDRSRRYI VGDNGHVNGG
     FAMLDFDLNY DTIYMENDVD SWIPRVRGMD DGAMETNLAV LRDPKEVVVK FNPVFHESID
     GTESVASDRD ISELGSDTDS AVYGKETSGA AYTLAQTLAN KVHQVFGKPR KFSITNITRR
     LSRGGADSER ESRPVSGRRM RDSVPEDIKF DSIVEMNWHA GKDVERPNYR RTSVAQQKSD
     TDSNSTESDS SRPFPTRFPY RKDSVLGTII HRNGGETVQS DSETPQSSGS DTGSVVIHEV
     DNGSLSDVLD SCKTTPIRSF LFSSFANRSN FSCNLVSDDD TSSVASSIAE SYNAQSIRLI
     MRTDSIQRRG KRPILRTSHR RGSDASTSSK DTQSSMSSVN TVSSSREFTR LANIINKRVT
     FADEKYGPGG LVISRI
//