ID C3YZ38_BRAFL Unreviewed; 809 AA.
AC C3YZ38;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Caspase family p20 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_66918 {ECO:0000313|EMBL:EEN54546.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN54546.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN54546.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN54546.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; GG666565; EEN54546.1; -; Genomic_DNA.
DR RefSeq; XP_002598534.1; XM_002598488.1.
DR AlphaFoldDB; C3YZ38; -.
DR STRING; 7739.C3YZ38; -.
DR eggNOG; KOG3573; Eukaryota.
DR InParanoid; C3YZ38; -.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..687
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 717..805
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 687..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 92179 MW; 7AD661CEBEAF822A CRC64;
MWRQHVMTEQ IFREDKERET YRDVREGEKR GKLPFNRSKV LFVGDTWQGK TSLKKRLTGQ
EFDPHEGRTE GIQTKMVETQ EVDQTWATRH HNESDYSRSL AWFVAQRSKK RPKKGATKDL
GSLMKTASFY FVLSFLAVTA LEFGSRVGYA VASLLLTSTI FMMHLNSDFY HVTRIASAIA
VNSVFIGVMK NGVEDLYQSI GPILSMGPFS LQGFVFCVTV LVDAMKSITT LPRHTAELPT
YRERHAMLRA QGILDGDFLA EVLNEVKPDH ADVLTTLLVS HDFLCPLPQH PADKKSPLMK
QRYLVPPMLP RYETDQPGGL FEKHHDDDNV EYYIDFDSFE PSPVFYRLVA KLVCETDFKI
RARGAPFVFK DRACFQLHRL FYFTLELVRA STDQHLIQIT VKKTSSTAAD GQLIKELHGK
LEMIRQRDFP CLTYTMGPRC PHPPPHLDHS TEPGAVHVVE VVESGEEFPD STQPLKLLCR
DREVVVDMSV PTQERSFQPT ASAYAGRCRH SQPSTIVIQE TAPPSDLLPK PDEHGLYDVK
RWLQVAQDPE SAFDKGECYP MWKRPRGDAL IINNRDFVTM ATRHGTDVDA ENLERLFEAL
YFTTERWNNL RAPVMKLVLE DFAQRSHAQS QCCLVAILSH GGDEGVYSTD EQLLSHADIL
SKFDGNNCPD LSSKPKVFFM QACRGTDKDR GSPATDSGET FRKHETARTS PDTHRTFSTR
VPNLTDVYLA YSTTPGHVSW RDCEGGSWFI QVLVSVFLKY AATKDINQLM TKVNHEVSRK
FESDKHDKQM PAPVNMLTKD LFFCSGWHR
//
