GenomeNet

Database: UniProt
Entry: C3YZ51
LinkDB: C3YZ51
Original site: C3YZ51 
ID   UBA5_BRAFL              Reviewed;         405 AA.
AC   C3YZ51;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=BRAFLDRAFT_113714;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae;
OC   Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82; TISSUE=Testis;
RX   PubMed=18563158; DOI=10.1038/nature06967;
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J.,
RA   Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J.,
RA   Jurka J., Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E.,
RA   Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y.,
RA   Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A.,
RA   Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; GG666565; EEN54559.1; -; Genomic_DNA.
DR   RefSeq; XP_002598547.1; XM_002598501.1.
DR   UniGene; Bfl.404; -.
DR   SMR; C3YZ51; -.
DR   STRING; 7739.JGI113714; -.
DR   PRIDE; C3YZ51; -.
DR   GeneID; 7219925; -.
DR   KEGG; bfo:BRAFLDRAFT_113714; -.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   InParanoid; C3YZ51; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071566; F:UFM1 activating enzyme activity; IBA:GO_Central.
DR   GO; GO:0032446; P:protein modification by small protein conjugation; IBA:GO_Central.
DR   GO; GO:0071569; P:protein ufmylation; IBA:GO_Central.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    405       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391935.
FT   ACT_SITE    248    248       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       224    224       Zinc. {ECO:0000250}.
FT   METAL       227    227       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   METAL       306    306       Zinc. {ECO:0000250}.
FT   BINDING      81     81       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING     102    102       ATP. {ECO:0000250}.
FT   BINDING     125    125       ATP. {ECO:0000250}.
FT   BINDING     148    148       ATP. {ECO:0000250}.
FT   BINDING     182    182       ATP. {ECO:0000250}.
SQ   SEQUENCE   405 AA;  44879 MW;  3E3101AC769D55EC CRC64;
     MATVEELQTR VKQLEEELER ERTRNRGGTD GGGGRKKIDQ MSSEVVDSNP YSRLMALKRM
     GIVDNYERIR DFTVAIVGVG GVGSVTAEML TRCGIGKLLL FDYDKVELAN MNRLFFQPHQ
     AGLSKVQAAE ITLRDINPDV EFETHNYNIT TVDNFQHFMD RISHGHLKGD RPVDLVLSCV
     DNFEARMAIN TACNEQGQVW IESGVSENAV SGHIQVIKPG ETACFACAPP LVVASGIDEK
     TLKREGVCAA SLPTTMGIVA GFLVQNTLKY LLEFGSVTYY LGYNAMQDFF PSMAMKPNPN
     CDDSFCTKLQ TEYQEKLLAQ PKEEAKEETV EEVVHDANDW GIELVAETTE EELKAASHGH
     VPELVEGVHV AYVRPMTQED EEGAAGLTVD DQESLEDLMA KMKSI
//
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