ID C3Z339_BRAFL Unreviewed; 481 AA.
AC C3Z339;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=MACPF domain-containing protein {ECO:0000259|PROSITE:PS51412};
GN ORFNames=BRAFLDRAFT_65208 {ECO:0000313|EMBL:EEN53078.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN53078.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN53078.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN53078.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GG666575; EEN53078.1; -; Genomic_DNA.
DR RefSeq; XP_002597066.1; XM_002597020.1.
DR AlphaFoldDB; C3Z339; -.
DR STRING; 7739.C3Z339; -.
DR eggNOG; ENOG502QU3G; Eukaryota.
DR InParanoid; C3Z339; -.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005579; C:membrane attack complex; IBA:GO_Central.
DR GO; GO:0006956; P:complement activation; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF8; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..448
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 406..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 80..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 481 AA; 51954 MW; 0D565CFA121D897D CRC64;
MAHTKASKKV QPCNTFTCPV DCQVGDFGDW SVCDPCLHTQ PLVETRGCSP DRTCPLTSGC
TSGQFKCVTT GRCVPASFRC NGDDDCCDQS DEQECLDVQN LCEGKTVEGL IPNIDIAGSG
YNVLTEELSG QVLDNSKYGG QCRIVYSGDH GKTFRLPHNT QFYRFQVVAD TSFRAEQFSS
SKQFYQDTSA KRQRDIHTDA STSFSVFTAS AEVVSSQSHG NHDVLKSSQD SDSALLTVSN
QIELAQFRIN GGSNFILALE ELPVVYSYAE YKKLIVDFGT HYVSAGKLGG QYRYAYRYNR
RNLTESGLSD EQQKSCLSNE AKASFLGISI GGGFKKCQNN KLSQQTAVRA LVQYLDEFHP
CKCAPCRNNG KAVLIGTACE CVCAEGTYGA SCEKVADPSL AGTTLFPDAP PTPVPRTGDK
VSAGQVGEPG NTASQGLGLA IGLSVAVVIC LAVAAALAYK YRRHGRPHSQ SETRPMVAQH
L
//
