ID C3ZC29_BRAFL Unreviewed; 417 AA.
AC C3ZC29;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Insulin-like domain-containing protein {ECO:0000259|SMART:SM00078};
GN ORFNames=BRAFLDRAFT_121099 {ECO:0000313|EMBL:EEN49801.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN49801.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN49801.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN49801.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; GG666606; EEN49801.1; -; Genomic_DNA.
DR RefSeq; XP_002593790.1; XM_002593744.1.
DR AlphaFoldDB; C3ZC29; -.
DR InParanoid; C3ZC29; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT DOMAIN 69..226
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 46755 MW; D1B63E2B245447F2 CRC64;
MPILTGQVWI TCGQRNGNYR IHPISGLPFQ DKQAGISSDV QATGMNLSSV YVLASLAVVC
LLVKETQAEY LCGSTLADVL SFVCGNRGYN SQPRRSTPLG VAYSVATRQL CYSNFPVLSE
QYVFLFGPNL KDGTWRGVFS PGCERRVLIN RWKPRKGGAH EIPVQGRPEA GLQTLMRRGA
SAQVDFISEQ QAKDYMGAMP HIRRRRGLVE ECCYNVCDYS QLESYCNPYT TAPATATPVR
TTEPQPEEAE DDPLDGMVGD QAPLGSIENI ENLVYHYDSD DITIDAAKKE PKKLKEILGS
FEDKKANPVF PFIRQSKNIK PNKFPDNFAH QYPTDLVEEG PTNEIPESPS QKPTLERLGY
KHNQTDKKQP TENNNNNNRA RDNRTKSSTV EPHTVPEYIS KQYTHKPLIT LPRVNVR
//
