ID C3ZG98_BRAFL Unreviewed; 3167 AA.
AC C3ZG98;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0000259|PROSITE:PS50945};
GN ORFNames=BRAFLDRAFT_67274 {ECO:0000313|EMBL:EEN48419.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN48419.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN48419.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN48419.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666617; EEN48419.1; -; Genomic_DNA.
DR RefSeq; XP_002592408.1; XM_002592362.1.
DR STRING; 7739.C3ZG98; -.
DR eggNOG; KOG4261; Eukaryota.
DR InParanoid; C3ZG98; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 3.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981:SF1; RHEA, ISOFORM B; 1.
DR PANTHER; PTHR19981; TALIN; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF21692; Talin_R4; 1.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 2.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 2920..3159
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 504..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1495..1575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1808..1840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1983..2010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2112..2272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2312..2414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2440..2547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2568..2603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3083..3147
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 504..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..898
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1911..1939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2055
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2056..2075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2112..2126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2197..2225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2250..2268
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2345..2367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2445..2466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2579..2603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3167 AA; 350561 MW; 5F3C12C169E8589B CRC64;
MNNAAHEIGK NVDGVASAAK EKAEKLGHQL AMGSFYCHEK AQKVTQLSSY FDPLASAAIN
LASKTMNSQK QENILEQTKT VAESALQLVY TSKEGGGNPK ATHAHAAIDE AAEGMKEAVD
DLLKTLDESA SETGAVFGMV DGITKAMSDM VDGRLEDKPA GSFVDYQTKM VKIAKQLART
SHDMVGKASS SPDELGPQAN ALSHDFSELA AQSKGAMATI NSPELSDRIR NSVQDLGNSC
VDVVNNAGAI QSNPSDTYAK KDLIENSRAV SEKVSFVLAS LQAGSRGTQA CINAASTVSG
IIGDLDTTIM FASAGTLSPE MEDEAFADHR ENILKTAKAL VEDTKTLVSG AASSQEHLAA
AAQSAVDTIT KLADAVKSGA ASLGPQDAEA QVLLINAVKD VAVALGELIE ATKNASGKPV
QDPSMVQLKN SAKQLLLDIQ NQYQVTKPNQ PRWENYINSL TTEQTKKSST SRTYVTKTST
SQVVTTKTQT QGYMVGRTVE RKEIAQDEKK AERNHVSLPP PRKMLRQPSP GYSDMSDTER
TETPVHELAE EPSENVFDIV KRFETPEMQR LYIEEGRDSP LMRRLSPSPR PESPLINRHA
KSVTRTTEVQ SPITYVVERV ISPTADKSPD VDNGPTKALR PKSPTPESQP ALFPGRKSPI
PGRKSPLLRS QSPVPGKRSP LLGTQSPVPG KKSPIPGRLS PGDRPRSPYL NVVHSSTERP
LTPEPHTRTL DLRPLSPSWK GSDADGRMEK KVQFTKVVVR ESTDRELENK LKKRREIADS
VIVGEQPSEM GSGRGGEGGL VEDRVEVTAP DVEPEVYGSQ SMVRSREAHK VSMDEEALVG
DVVQEESSSI PPCSTASPVV HPLPDDVPTV SEPSQLPRGY LATVSMQPPP PLPEPPAIHP
ADHLASVSEQ PLPEPPVIHP YDHLATALEP PAIHTPPLPE PPVIHSPDHL ATVSELPVIP
PPLSEPPSEA LKPPDLVTEV DGVTEEVEAL ETVEMSTDLV PPPDVIEIKE RKEEETSSIH
ITTSTQQTQM ETEETATASE TVREEEGKDD TETAERSSYI GFDSPVPEEM AEVAEGGQKG
VSPESLAKIA ADKIQESELE ESESDTDIEM CYDVTPGGLE TIYELSDEQE DPHSMEFEHA
LENVQFDEES GRWFAATGLK PAFARKVLVQ KKKQVEKIVE EKEEEIEEER KLETDSIPTE
AGKEEGLFRG LPIVRERKWD EKFRQEEEER IIKELAEEEE RAIAFKKAEE ERAIAFKKAE
EERAIAFRKA EEERIAEEER QREEAKMFRG IPLVRERKWD ERFRQEDERR LMMELSTTEA
ADLEVTKDEE IRRDDVLVDD VSRQQPVELV EIPSLLEEED DVFLPEKPAE ILKEEPEMMP
KEKTPSPPPQ EDVKKLTTSS EAPVVEKEVV QPDSEPTKDV VEDKPVQEPR ITETKPNETS
VEKKGRVTAA EVAALPSFTA TVSELPVIPP PLSEPPSEAL KPPDLVTEVA QVTEEVEAPE
TVEMSTDLVP PPDVIEIKER KEEETSSISI TTSTQQKQIE TEETATASET VTIEEGKDDT
ETAERSSYIG FDSPVPEEMA EVAEGGQKGV SPESLAKIAA DKIQESELEE SESDTDIEMC
YDITPGGLET IYELSDEQED PHSMEFEHAL ENVQFDEESG RWFAATGLKP AFARKVLVQK
KKQVEKIVEV KEEEIEEERK LETDSMSTEA GKEEGLYRGL PIVRERKWDE KFRQEEEERI
IKELAEEEER AIAFKKAEEE RAIAFKKAEE ERIAEEERHR EEAKVFRGIP LVRERKWDER
FRQEDERRLM MEHSTTEAAE RDLEVSKDEE TRGDDVLVED VSRQQPVELV EIPSLLEEED
DVFLPEKPAE ILKEEPEMMP KKKTPSPPPQ EDVKKLTTSS EAPVVEKEVV QPDSEPTKDV
VEDKPVQEPR ITKTKPDETA VEKKGRVTAA EVAALPSFTG LKKTYAEVVK LGIMDKVGTQ
TRKEEYKAPS EMTTLLPKPQ KKQSPSFEID VQRKATFETE FSRSPPKVQF EDMTVVMEMS
DEEMVREEEQ EASPAEEEQN LSQEPNLSQE ASHSSFESET DFEVAKLWKR SEMAMMPGLE
KGLEEGKLYE ATNFGDKGEH DKVSTVEMLS KSPPKVRFSP VVEIIQTREI EQTMSEQLSS
ETNSSDEDES SASDAKDSDD HDSGGEAGGP AEEDAGGADQ EKDDDDGPDE RKDEEDADED
SREPTGEPEQ DAAMLSAESE LSASEDNLGE EVSSEMETDQ DNDQDIFEEL IQDNMKRMEE
LLHHKENLAQ EKEQFHQQAA LYSLAVKVSE NRGAKRRLQR VTRSNTQALF GDDDDEEEEQ
EEEDTGKTAE RSGVEQLEGR VMDVDTGSDS EWSKQLATGP GIEQLEIARK LSPQETSMTK
EPAPEEASEE ELEKVGSWNM ESIIADLMQD YYLLEAEWDT EASETEASQD TSSEAAGPSA
SSQKHTAAVP DRAAREQYDG FPSPPDMSLL GQDGGGWGAE DATNKDHQEQ YNQQRNDQSQ
VPLTEGTDIP WGGEEELPPP PFFDFSEEGA MEDCHRYYDS DTYGAARETA GASREFPAFD
GQRGEDRRGE GRRREGEESK EDELARMIRL ASCELYGGAD SPRIMHKQRS TSDLMATDTS
SIASSSRTAS ASDLAELLQE SASEDLEFLE KYSKEGRKMR KRKVRVESDF RSHLEKILRK
RQEKMSEKGS STPELVKMFR SESMESFLSK ELEEKKKKIG GSVPSSPVMV TNVTSLLKTV
KTVEDEAARG TRALEATIEA IKQEMRILSS MDPPEKRLPP EDLIRSTKPV TLLTAKAVAA
GTSCRQDDII AVANMSRKSV GDLIVTCKAS AFGAESRETT ERAMEVGRNT VSMYVELLMH
VLSILQKPTH EGKQKLAHFS KRVATAVAEL VQTAEAIKGS EWVDPEDPTV VAENELLGAA
SAIEAAAKKL SELKPRPKAK EVDETLNFEE QILEAAKSIA AATSALVKAA STAQRELVAQ
GKVGASRAMA YDDGQWSQGL ISAARMVAAA TGSLCEAANE MVQGLASEEK LISSAKQVAA
STAQLLVACK VKADPDSEAM RRLQQAGNRV KHASEELVKA AQQAAAIEEE ERNIELSKRR
VPTIAMEIQA QEEILRKEKE LEEARKMLFA IRTAKYKNRP HHQDDSD
//
