ID C3ZGU2_BRAFL Unreviewed; 865 AA.
AC C3ZGU2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Ras GTPase-activating protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_206850 {ECO:0000313|EMBL:EEN48318.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN48318.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN48318.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN48318.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666620; EEN48318.1; -; Genomic_DNA.
DR RefSeq; XP_002592307.1; XM_002592261.1.
DR AlphaFoldDB; C3ZGU2; -.
DR STRING; 7739.C3ZGU2; -.
DR eggNOG; KOG3508; Eukaryota.
DR InParanoid; C3ZGU2; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..865
FT /note="Ras GTPase-activating protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002936382"
FT DOMAIN 61..123
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 133..256
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 292..394
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 395..508
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 565..759
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 865 AA; 99026 MW; B3B393F26D493A05 CRC64;
MRFHDKALFL LCRIIAMCGD FYLGGRQFDS LSDLIGYYTI WACILKDEKL MYPVPPPEPV
QSRRLVRAIL PYTRVPDTDE LSFEKSDVFM VHNTMDGGWL WVTSQRTNES GLVIRDLVEE
LDFYADPHEG KEWFHGTITK EKAAQLLSGI FFSVYSAFLI RPSDSSPGDY SLFFRSNNMI
QRFRITRQNH EEFEMGGHHY ATYSDILPIC YTTLLKFLVS CGNFIFSPFI PSSLDDIIKH
YKTEQIVEGY TLGEPVPNKV GHEGQKIDFC VIAMIIFFFL KLVICTSYFN STVTVTWSLY
FSGHRSKKWK NLFFILNGTE QHVYYFENEK RTKPKGLIDL NYASIYPVHE SLFGRPNCFQ
TVVRALNDVT TTYLCADTAE LAKEWILAMR QFCTQPSNKQ SPLNAKRVKQ LRSLSVNVLD
ARNLPVKHLP HPYCMLSLHD VHAARTQMRE GPNPLWSEEF VFEDLPREVE SFTLLLCSRA
RRSKDAVVAS VYVPLSKLPN GQYVDEWYPV IPESPYKGDM GSIRIRAHYR SQLVLPLEEY
AGLKQLIVSK EFHTIYALDK VCARDRSLLA SALLRVFRDE KKEAVLLQTL TTKEIANEDE
SATLFRATTL ASTLMDQYMK MTAVPFLHQA VKDVITKIAD SKQSCELNPT KLEKGADVNS
NLETLLSFLT EAVEAIFKAT ESCPSTLRYI FGCLQREVLK KWPDDTTMRT RVVSGFIFLR
LICPAILNPR QFNLLAESPT PTAARTLTMV AKSLQNLANL VEFGAKEPYM EAVNPFIVKN
KERMIMFLDE LAVRIPTSPC HLMCECVYVC ECNVPSYPEV TEKVKSDPSQ DLATLHQICL
SHLTELQTLS TTQVRNHNTI KLQNF
//
