ID   C3ZIR8_BRAFL            Unreviewed;       204 AA.
AC   C3ZIR8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN   ORFNames=BRAFLDRAFT_108434 {ECO:0000313|EMBL:EEN47603.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN47603.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN47603.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN47603.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
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DR   EMBL; GG666628; EEN47603.1; -; Genomic_DNA.
DR   RefSeq; XP_002591592.1; XM_002591546.1.
DR   AlphaFoldDB; C3ZIR8; -.
DR   InParanoid; C3ZIR8; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        67..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          124..193
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   204 AA;  23986 MW;  856C0FFBFB80EBD5 CRC64;
     MLRMKRKNNQ RRKFYFVLRE YSILFLFVVV LFFISQQDID PFSFHASQTL STALTKDFDS
     ITTPEDFWAW TEVILLPALY PTFWYNGWKM KYLDRQFPFH TEAFRIGPPR LSQIREAAGE
     LGVEHFVDFE STFWWDEAFK SVLAILVFLN TLTLLRVVRF SKTIAKFIAL PGAMKNDLIA
     FSITSVVAFM AFSSSETAYD MHFM
//