ID   C3ZJ17_BRAFL            Unreviewed;       574 AA.
AC   C3ZJ17;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEN47446.1};
GN   ORFNames=BRAFLDRAFT_205481 {ECO:0000313|EMBL:EEN47446.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN47446.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN47446.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN47446.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the eIF2D family.
CC       {ECO:0000256|ARBA:ARBA00010359}.
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DR   EMBL; GG666631; EEN47446.1; -; Genomic_DNA.
DR   RefSeq; XP_002591435.1; XM_002591389.1.
DR   AlphaFoldDB; C3ZJ17; -.
DR   STRING; 7739.C3ZJ17; -.
DR   eggNOG; KOG2522; Eukaryota.
DR   InParanoid; C3ZJ17; -.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   CDD; cd11608; eIF2D_C; 1.
DR   CDD; cd11610; eIF2D_N; 1.
DR   CDD; cd21156; PUA_eIF2d-like; 1.
DR   Gene3D; 3.10.400.20; -; 2.
DR   Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR   Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR   InterPro; IPR039757; EIF2D.
DR   InterPro; IPR048247; eIF2D_N.
DR   InterPro; IPR039759; eIF2D_SUI1.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR048248; PUA_eIF2d-like.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR   InterPro; IPR003121; SWIB_MDM2_domain.
DR   PANTHER; PTHR12217; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR   PANTHER; PTHR12217:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   Pfam; PF02201; SWIB; 1.
DR   SUPFAM; SSF55159; eIF1-like; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS50296; SUI1; 1.
DR   PROSITE; PS51925; SWIB_MDM2; 1.
PE   3: Inferred from homology;
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022540}.
FT   DOMAIN          377..459
FT                   /note="DM2"
FT                   /evidence="ECO:0000259|PROSITE:PS51925"
FT   DOMAIN          483..556
FT                   /note="SUI1"
FT                   /evidence="ECO:0000259|PROSITE:PS50296"
FT   REGION          173..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..255
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  63627 MW;  33E8EB5A50E3F504 CRC64;
     MFQKPFRVKS KTVIRGSDRR KLRADVGKAL PSLTEDQLQE MVPTKEDMSI MKICIKRTNC
     NDNVRNYCKC RNYVFVCYER AGFATVAHEV FTNIVPSLPP DLMLPGVIPG EEGLPGIEKN
     SLCAISLLGN RAPVAVGRTM MSSSQMQECE MKGKGVTVLH TYLDQLWEHG DQTPLPTMAT
     QQSCPEGHVP DLDSGDATSE EQLQGQLAAE ASSTTDTVPI ENLVLNDDLG DEGGVKDDGN
     ECGEEEGETR DEEDEMDSLL YQCFLHALKT NVKKTDLPLL TSKLLRGHMQ PCCPAEKSLD
     LKKSSYKKLS KFLQAMQTQG LIQVKELSKG VESVVEVNRG HEELKSFEVP DVELPAVEVN
     DPGTAAGPTY QPPEVVEMFS VTGNLAPLFR TAGIRKGHAL SGQEVREFLT QYVKENELVD
     PNNKRYIVVD PLLCDALRQK GEDLTHLTWE ELFTRCCDKM SPCAQLIFPG QPPILKKGKL
     EPVDVQVQQR SGNKKVTLIY NLEGFGIRPD TFAHLLQLRV QASTAVNPAP NRKAGVQVMV
     QGNQVHTVAK LLIDEMKLPK KFVQGVEKAA KKKR
//