ID C3ZPZ0_BRAFL Unreviewed; 931 AA.
AC C3ZPZ0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Death domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_77807 {ECO:0000313|EMBL:EEN45369.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN45369.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN45369.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN45369.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666659; EEN45369.1; -; Genomic_DNA.
DR RefSeq; XP_002589358.1; XM_002589312.1.
DR AlphaFoldDB; C3ZPZ0; -.
DR STRING; 7739.C3ZPZ0; -.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; C3ZPZ0; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF43; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 15.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 556..623
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 588..899
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 509..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 105236 MW; 36ACFDCCE27E4DAC CRC64;
MAAGLNLQPQ TVDGRLTLDL TNQGLTSIPE EVFDITDLEA LDLSNNKLTS IPEAIGRLQK
LYRLEVHANM LTSLPQAIVT LQKLTHLYVY RNKLANLPPG IEKLQKLTLL SIFDNQLTKV
PPGVCMLPSL EELDVSKNKL STFPPGVEKL QKLRKLYIYD NQLTEVPSGV CSLPNLEVLG
VGNNKLSTFP PGVEKLQKLR ELNIYGNQLT EVPPGVCSLP NLEVLNFGNN KLSTFPPGVE
KLQKLRDLYI YDNQLTEVPS GVCSLPNLEG LSVYNNKLST FPPGVEKLQK LRELYIHNNQ
LTEVPSGVCS LPNLEVLSVG MNPIRRLPDD VTRLTRLKTL GVPNCQFDEF PRQMLQLKTL
QKLYAGGCKF DMVPDEVGNL QHLWFLAVEN NLLRTLPSTM SHLHNLRVIQ LWNNKFDTVP
EVLCELPAME KLVIRNNNIT RLPTVLHRAD KLRDLDISGN PLTYPPQDVC KQGTGAIMAF
LKQEAEKASR QPDIMEPAAE TELERKLRER REKSVRMEQQ VSQQKDQTAE RMDKSKDKDL
NLAFSRLALK VKQSVEWKHI ARQLGFNNQE VKDVETDCPD EPMYETLVRW RERAGPAASL
AVLERCLRDL DLHQLADQIS RTAMSQTQIG HESEEGGAVG GQLPGEVQSS EQDLLYSEAR
KLNLGSRSDH VISLLGVCLD PNFAIVMPYM ENGSLAGLLR DVDVPWALRW RMAHEISLGM
TFLHCQNPQI LHCDLKAENV LLDGDFHVKV EMTSFSNKRG CSLIILPLHS IVIMTENFIY
KPFFAIDFLY VTGKRQHGYI SNREDVTSVS QLMQTCWSQN PDDRPSFDDC ADRLRHVKDR
FSREDVRQAI STVEKMQSSS TTKMTDEQQQ RVNKYMGQFG ELNSELTSAR NLQCARQFVI
LTNSVGIAGV IGTLERFREV FGRYCTCISR V
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