ID C3ZSI0_BRAFL Unreviewed; 2184 AA.
AC C3ZSI0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN ORFNames=BRAFLDRAFT_63321 {ECO:0000313|EMBL:EEN44382.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN44382.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN44382.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN44382.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666674; EEN44382.1; -; Genomic_DNA.
DR RefSeq; XP_002588371.1; XM_002588325.1.
DR eggNOG; KOG1840; Eukaryota.
DR InParanoid; C3ZSI0; -.
DR GO; GO:0008773; F:[protein-PII] uridylyltransferase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR005105; GlnD_Uridyltrans_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR19959; KINESIN LIGHT CHAIN; 1.
DR PANTHER; PTHR19959:SF118; LIPASE_3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF03445; DUF294; 1.
DR Pfam; PF13424; TPR_12; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 659..692
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 703..736
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2119..2184
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 853..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2184 AA; 246421 MW; D2B347FE79C08994 CRC64;
MDVGGSEGDN STYQELMQDG CKALQIGDLD KAEKSFAAAL KSVHSQGGHR KEAEPLHKLG
DVYLKRGILS KDGGDFTKAA ALCNAALVRS RREDVEESIQ EISRAFVKEV LGTEKACSDD
TEKHKIMLKA DRYYVEKEIN TIEAYVDPYS LDDDNPTLRE VEKKRAEAIK ALFDTIVHQR
RTFVTGLVEE CIEVMGPPPC TYAMIGMGSD ATGLATPYSD LEFAILVERE TDRNVTYFRN
LTHYLHLKVI NLGETIVPAM GIRSLNDFYS DDLLGNWFYD SVTPRGFDFD GAMPHACKSP
LGRGSTKELI RTPSNMTSIV KDDLTFHLKK GYHLASMLTN VSLITGEQGL LDEYKSLLNQ
QLQENSKLPL LMANTTLNEN VPIFQLHALT PSLLNVKKDI YRFSILAVSC LALIHHIIPT
TIWETIQKLK NSGVINSENA HHLMVMVTIS AELRLRTYMN NRGRVETMSA LSSMSPDTEI
GAKLRKVFHL SNRKQLMRYY YTERPLKHFI SQLREGRVQK EQSFLFDNSS ELKAEVYESL
CDFESSKTCK EQTLQKYLSK YGEQSAHFDI ANSLGNLGTS LISLGEYIKG IRYHEQALQM
RRSIYGEDTT HPDIATSLDK LGAAWTYLSD HRKAVSYHEQ ALQMRRSIYG EDIAHPDIAT
SLDNLGAAWR HLGDHRKAVS YHEQALQMRR SIYGETTAHP GVATSLDNLG AVWRHLGDYR
KAISYHEQAL QMRRSIYELS STPIEMFSPE MARLYAEACR QGSLPVHSPE MARLYAEACR
QGSLPVHSTR AQVVGQFRSG KTCLIKRLMG EEVIEEEVEP ITDGINIIPD VQTKTWTKSG
EEIDDLAGTL LQTQQKTEPP QANVTRYIAQ NDDTTETTQQ ETKKAPEDTV EDHDQGKDQI
PQVENLEDKT QPDLPAATSE EPTKVEVNIS GHAKLTLETP DAKTAAVGKP SNIEDEMPEH
LRENAARMIK AGITEEELGT ADHPRLSFWD FGGQATYYGT HHCFITPRGV YILVMSLLQK
LSDPVPDPDR MASVDNLRTG GEYLDHWLNS IRSHTQHNKE RPPVIVVLTN KDKVSKGYIK
KHKRKIRRHI EGKSAGLLVM SKIFAVDNTT EDAVVDEIRK YIRQVASKLP HMGEKIPISW
LHLKSELTKR REGGDRFLKF QDIAKLSRDS AINITDKHTL AMVLTFFHDR GDIIFFDEPD
LRDDVTLQPQ VMIDVFKTII TIPKYQQDRG TNQEMKEMWE RLEKEGVLSD KLLTRIWEKK
DEQLKEKGKN PFLLKHKSLL KALMEKFYLI CNATAISDAS DEGQHEEIYF VPALLSCKRD
NAVLYPGNMH IYPQSLYFVF SETFLPSGMF CRLQALCVRR FGLEESRVFA GCGRFPTDDE
KQSFVVTKVD HYIKVELLSS TNVFKEEEGL RVRKFLSSAL FEIKEKWIPC IQYDLCCSTQ
EDGCGPPFRK LSTVAGSVER DSGIPSAFRS VWMAGSPQIH RAEAPRDEGH KVLHPTEDPD
TIREMRTIGP VLDIMEQAGG LTLDQCDHIR SQLTPVERVL EMKKRGEVDP YLLGAAVEMS
SPEFVDLFSR KKRGKKLVIL HTNDFTPEFI SPLLEVADKS GVPYDTVTME QTDSITVKTV
ELLLNRNNRM VLLVISPQAL KNWSNLDYEF AIRNRKLLLP ILLHPQDGNR KWMDQVLQQR
SPVLYSQEHE DLQMAGGAVP QEKLQGIVHN AVFGGIFSPL DDTAFRSLLK VWSARTEQES
QGIKAPQDLM REMAKTGYIT HGDLAKLEND MVATGISFPV IVRDIPVPDE SQDQRGTEAS
VGPEGGDVEI SGFVKLAVPK NALQKSTSIT ISTIDIPSIL RGPGGVSWTS GYPWSLENAC
PRDLLDQVLF SPAFDVNLDG AQLNGPAEVE TWRPPGSQGM ECILLKHHDG EGWTDITSSV
DLQTHPNRIS FSMQSFSRVS PIWCPGSAID KILKTVRRAL SSRSLKSCSF VAYVKPIPNV
QSLPEQVNFH VVCRDECVDT DEYDSGFARC GKNYAESSLY HNDIIEVTVS VYGNKKTKDM
TLQEKICRRK SGQSLQMLLD RPHGRRSLVG EVEIVKKANV ETTSLVKRVC HLVIVEEGDK
TNLDVEQCFD YVIKEVSSKW DDLARKLGFN ENKIRVIQHS NRDDDHMCRE VLKQWRNDKG
SKATLQVLQQ ALIDIGQTLT AESL
//
