ID   C3ZSN1_BRAFL            Unreviewed;       373 AA.
AC   C3ZSN1;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=BRAFLDRAFT_199073 {ECO:0000313|EMBL:EEN44433.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN44433.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN44433.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN44433.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; GG666674; EEN44433.1; -; Genomic_DNA.
DR   RefSeq; XP_002588422.1; XM_002588376.1.
DR   AlphaFoldDB; C3ZSN1; -.
DR   STRING; 7739.C3ZSN1; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   InParanoid; C3ZSN1; -.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475}.
FT   DOMAIN          10..293
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   REGION          130..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  41167 MW;  25C84CB8D6EBA261 CRC64;
     MTKTEGLTYV VTGGCGFLGS NIVDMLVQKG TNISEIRVVD TKLDNFKSPE KKGRSRIKVT
     PIRGDITDVA QMTQVCAGAD VVIHTASVID VFGLVSEGTL WNVNVKGTET LLQCCVNQDV
     RSFVYTSSRE AVGPNSRGDP LEDGDENTPY DSSSPLLPYG RTKAAAEAMV LQWNGRRTDG
     GKTLHTCSLR PGGMYGGSGW TVMRIWQEFG KELFKKPQKR ISRPSVKSSC PYVGNVAWAH
     LLAAQTLLTS PNNAGGEAFF IDDDTPAKDE GALYGELCAP IGISWDDSLV LPLPILYSIA
     YALSFVKFVC KPFYTFVPRL TPAVLTIVNT NFYFNYKKAT RLLGYKPLFS WEESKQKTWD
     GLLEWKAREF DAY
//