ID   C3ZTD8_BRAFL            Unreviewed;       687 AA.
AC   C3ZTD8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=BRAFLDRAFT_68813 {ECO:0000313|EMBL:EEN44185.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN44185.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN44185.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN44185.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
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DR   EMBL; GG666677; EEN44185.1; -; Genomic_DNA.
DR   RefSeq; XP_002588174.1; XM_002588128.1.
DR   AlphaFoldDB; C3ZTD8; -.
DR   STRING; 7739.C3ZTD8; -.
DR   eggNOG; ENOG502S375; Eukaryota.
DR   InParanoid; C3ZTD8; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd00821; PH; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   PANTHER; PTHR21258:SF56; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          5..121
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          265..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          601..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..632
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..662
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  74867 MW;  670F9DE30E2EB059 CRC64;
     MAENKVVFKG WLEKCKNVQN PQKGFQLKLK GSVSWKRAFC ILHHCHGNST LHCFDDEPKE
     DTIPKGSLSL GPYYCVYKRD GQVKGRTQVF DVTTPAATWR LAAADQTSLD LWVHHLQIQA
     KLRDDLPGQY FTVRPAVSES AKRIGAQGQQ CLLHVSQWGI TLAQEWPLKS LRSYGAEDDG
     RFSFEAGRQA PMGQGVYVFH THPGQEVSID AQVDTFVQQQ AKMADQECPS VFAYNTPMGQ
     GVYVFHTHPG QETSIDAQVD TLVQQQAKMA DQEKAGRSPT KQETAVRRRG SSAQEPDPDM
     CSEYATLRRM TCHNTAVSPV DGRNQSSHLS FPQDTGAGLL IGSSVSQSQQ SSSAQDPASV
     GRSNVVTIPP PSSSSDCTNS TYLAMKASWS PRSSTTSQSV SSEYEAMSPL SSDHSSPFQS
     LPSPPGRSGS FQDVSVFPMS PLSNKSNSFD DVSVFSPTLS PSDSSSSYTA GQLASDNTTQ
     TMTTHKRSAS MGAGKPGENP FSFPTHPTTL SLSSTNAESR PVLHRSHSEG NIPPPFTNLA
     SNSPPKLPPK GVALMGRAMM SQRSLPPIPA SPLDANTMPF HFNERLNSSG SHEYQSLLTP
     EQTQRLKEAE SSYTEVTHRT RSNPEGQEHL HTSPHAEQSV STVGAEHTLE QVMQTSTKVK
     SPKSIKGLVF TRKTKTFVKR SKSSEGT
//