ID C3ZU23_BRAFL Unreviewed; 851 AA.
AC C3ZU23;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DED domain-containing protein {ECO:0000259|PROSITE:PS50168};
GN ORFNames=BRAFLDRAFT_87286 {ECO:0000313|EMBL:EEN43909.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN43909.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN43909.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN43909.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666681; EEN43909.1; -; Genomic_DNA.
DR RefSeq; XP_002587898.1; XM_002587852.1.
DR AlphaFoldDB; C3ZU23; -.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; C3ZU23; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00045; DED; 1.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR049341; TRADD-like_N.
DR PANTHER; PTHR10680:SF28; DED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10680; PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE; 1.
DR Pfam; PF01335; DED; 1.
DR Pfam; PF01436; NHL; 2.
DR Pfam; PF20694; TRADD-like_N; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS50168; DED; 1.
DR PROSITE; PS51125; NHL; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 18..96
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT REPEAT 584..627
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 768..811
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 100..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 115..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94581 MW; 6A3DAEB82CB2A060 CRC64;
MASPVRERVT DADRRHFDFV KTLLRISDEL TEEETANLKI FCLHLIPKGH LAQLRRAMDV
FVKLMELDKI DRENLDFLKE ILEGIGRQDL IRDVLRQFQP PDREIPENPD LQPENPGLQP
ENTDLQPENP DLQPENPDLQ PENPDLQPEN PDLQPENPDL QPQNSELQPQ NPELQPGDPE
IQSGQSNAEG ANEEGDATSN IYVVVHGQVR MIQEALDRLK GDLARLSGTR RSQVMYRGHK
KHKSILVHFS IPRENTAVLR HMADHSDPRL VYMGIKYLQI DAEVPIKVQQ EEPVYDIKRQ
LPVDDIEVGC STRTKHQKAP QSWSRLSALN LFSDALPLHL QAAASLEYQG FSYSLVRALV
QKDRLREHQM RQAIQNLRNA EVDSNTLRQK AEVDSNTLRQ KAEADSNTIM TLRSKLNITE
NRLKEALETI AVLQEKMKQA QEYAENAAKH VTSHVTEYRG EKPPGGWAQE YRGEKSPGGS
PLEYRGEKPP GGWSSQVEKA DSATQTHQTD PFGTTGIPGD VGGDKVGADP TVKEEVGKTP
TQDSGSGSNG KEDVLGTEAL EQERQTAGTA GTASGSTGDR KQRVITFGVM GTEPRQFLDP
RGVVVSPSNE IFVANRGNER VQVRSTEGVY LRHFPTVVPG TGDKVMVPHD VCMDANGTLW
VVGRGQTADH VVQYSTDGTA MAGFDLEKIG YFRGIAVNMR TNHILVTDAD QGEVHVFRPD
GSLVRTVRHP RAGKTRPRYI TVDGEGNILV SDWNNNYVYM YDESGEFLFQ FGGEGSGEGQ
LSGPSGICTD SSGHILVADS GNGRIQIFTR HGEFVRTVST GFTPYGLAVG PEGQLVVTNY
WKHTVTVYPN Y
//
